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Tbio
NEDD1
Protein NEDD1

Protein Summary
Description
Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266742
  • ENSP00000266742
  • ENSG00000139350
  • ENST00000411739
  • ENSP00000411307
  • ENST00000429527
  • ENSP00000404978
  • ENST00000457368
  • ENSP00000407964
  • ENST00000557644
  • ENSP00000451211

Symbol
  • GCP-WD
  • TUBGCP7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.86
histone modification site profile
0.75
virus perturbation
0.68
transcription factor
0.67
transcription factor binding site profile
0.64


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.57   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.57   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neural precursor cell expressed, developmentally down-regulated 1
VGNC:8474
452149
Macaque
neural precursor cell expressed, developmentally down-regulated 1
713673
Mouse
MGI:97293
17997
Rat
RGD:1307750
299730
Dog
neural precursor cell expressed, developmentally down-regulated 1
VGNC:43720
100855622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neural precursor cell expressed, developmentally down-regulated 1
Macaque
neural precursor cell expressed, developmentally down-regulated 1
Mouse
Rat
Dog
neural precursor cell expressed, developmentally down-regulated 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NHV4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (192)
1 – 10 of 192
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.999998308
p_ni:  0.000001692
p_wrong:  1e-9
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.99998601
p_ni:  0.00001399
Score:  0.267
Data Source:  BioPlex,STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999824587
p_ni:  0.000175289
p_wrong:  1.24e-7
Score:  0.263
Data Source:  BioPlex,STRINGDB
TUBGCP5
Tbio
Novelty:  0.04863776
p_int:  0.99950892
p_ni:  0.000491059
p_wrong:  2.1e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.998987693
p_ni:  0.000996099
p_wrong:  0.000016208
Data Source:  BioPlex
PARP16
Tchem
Family:  Enzyme
Novelty:  0.09651799
p_int:  0.9985436
p_ni:  0.001456398
p_wrong:  2e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.995051093
p_ni:  0.004925977
p_wrong:  0.00002293
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.984171137
p_ni:  0.015819504
p_wrong:  0.000009359
Data Source:  BioPlex
TUBAL3
Tdark
Novelty:  1.0330894
p_int:  0.982916649
p_ni:  0.012308282
p_wrong:  0.004775069
Data Source:  BioPlex
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.979826233
p_ni:  0.020162306
p_wrong:  0.000011461
Data Source:  BioPlex
Publication Statistics
PubMed Score  33.57

PubMed score by year
PubTator Score  17.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer