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Tbio
MFSD8
Major facilitator superfamily domain-containing protein 8

Protein Summary
Description
May be a carrier that transport small solutes by using chemiosmotic ion gradients. This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296468
  • ENSP00000296468
  • ENSG00000164073
  • ENST00000641434
  • ENSP00000493279
  • ENST00000641464
  • ENSP00000493438
  • ENST00000641686
  • ENSP00000493218
  • ENST00000641748
  • ENSP00000493330
  • ENST00000641928
  • ENSP00000493418

Symbol
  • CLN7
  • CCMD
  • CLN7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
histone modification site profile
0.72
tissue sample
0.65
virus perturbation
0.59
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.92   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.92   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0