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Tbio
MFSD8
Major facilitator superfamily domain-containing protein 8

Protein Summary
Description
May be a carrier that transport small solutes by using chemiosmotic ion gradients. This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296468
  • ENSP00000296468
  • ENSG00000164073
  • ENST00000641434
  • ENSP00000493279
  • ENST00000641464
  • ENSP00000493438
  • ENST00000641686
  • ENSP00000493218
  • ENST00000641748
  • ENSP00000493330
  • ENST00000641928
  • ENSP00000493418

Symbol
  • CLN7
  • CCMD
  • CLN7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
histone modification site profile
0.72
tissue sample
0.65
virus perturbation
0.59
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
p_int:  0.999997318
p_ni:  0.000002682
Data Source:  BioPlex
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.99938016
p_ni:  0.00060202
p_wrong:  0.00001782
Data Source:  BioPlex
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
p_int:  0.999212637
p_ni:  0.000774681
p_wrong:  0.000012682
Data Source:  BioPlex
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.997505031
p_ni:  0.002494966
p_wrong:  4e-9
Data Source:  BioPlex
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.996081503
p_ni:  0.003918395
p_wrong:  1.03e-7
Data Source:  BioPlex
CYB5R1
Tbio
Family:  Enzyme
Novelty:  0.07714146
p_int:  0.995678851
p_ni:  0.004321149
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.994621084
p_ni:  0.005376095
p_wrong:  0.000002821
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.994218651
p_ni:  0.005781099
p_wrong:  2.5e-7
Data Source:  BioPlex
KLRC4
Tbio
Novelty:  0.16922525
p_int:  0.994208203
p_ni:  0.005764337
p_wrong:  0.000027461
Data Source:  BioPlex
HLA-DQA1
Tbio
Novelty:  0.00077488
p_int:  0.994082648
p_ni:  0.005917248
p_wrong:  1.04e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
40.3
IGF-1 measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
40.3
IGF-1 measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 8
VGNC:636
471303
Macaque
major facilitator superfamily domain containing 8
713336
Mouse
MGI:1919425
72175
Rat
RGD:1310132
361939
Dog
major facilitator superfamily domain containing 8
VGNC:43208
476086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 8
Macaque
major facilitator superfamily domain containing 8
Mouse
Rat
Dog
major facilitator superfamily domain containing 8
Publication Statistics
PubMed Score 33.83
PubMed score by year
PubTator Score 23.66
PubTator score by year
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Related Publications
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PMID
Year
Title