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Tbio
DNAJB8
DnaJ homolog subfamily B member 8

Protein Summary
Description
Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319153
  • ENSP00000316053
  • ENSG00000179407
  • ENST00000469083
  • ENSP00000417418

Symbol
  • DJ6
  • CT156
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
tissue sample
0.71
cell line
0.52
tissue
0.51
gene perturbation
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
DNAJB2
Tbio
Novelty:  0.046216
p_int:  0.999999477
p_ni:  5.23e-7
Score:  0.215
Data Source:  BioPlex,STRINGDB
C9orf40
Tdark
Novelty:  2.72763898
p_int:  0.99850505
p_ni:  0.001490809
p_wrong:  0.000004141
Score:  0.28
Data Source:  BioPlex,STRINGDB
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.997678939
p_ni:  0.002321061
Score:  0.226
Data Source:  BioPlex,STRINGDB
THAP2
Tdark
Family:  TF
Novelty:  0.21339518
p_int:  0.961821881
p_ni:  0.000849946
p_wrong:  0.037328173
Score:  0.234
Data Source:  BioPlex,STRINGDB
ESS2
Tbio
Novelty:  0.00163665
p_int:  0.928312994
p_ni:  0.071484214
p_wrong:  0.000202791
Score:  0.205
Data Source:  BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.773989506
p_ni:  0.002154627
p_wrong:  0.223855867
Score:  0.211
Data Source:  BioPlex,STRINGDB
LCN1
Tbio
Novelty:  0.00510137
p_int:  0.771089589
p_ni:  0.22891041
Score:  0.214
Data Source:  BioPlex,STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.814
Data Source:  STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.791
Data Source:  STRINGDB
HSPA6
Tbio
Novelty:  0.00654285
Score:  0.787
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.1
90
neutrophil percentage of leukocytes
2
2
2
87
lymphocyte count
2
2
2
81
lymphocyte percentage of leukocytes
2
3
3
80.5
neutrophil count
1
1
1
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90
neutrophil percentage of leukocytes
2
87
lymphocyte count
2
81
lymphocyte percentage of leukocytes
3
80.5
neutrophil count
1
70
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B8
VGNC:11382
470916
Macaque
DnaJ heat shock protein family (Hsp40) member B8
705667
Mouse
MGI:1922801
56691
Rat
RGD:1561981
500253
Dog
DnaJ heat shock protein family (Hsp40) member B8
VGNC:54595
609460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B8
Macaque
DnaJ heat shock protein family (Hsp40) member B8
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B8
Publication Statistics
PubMed Score 14.00
PubMed score by year
PubTator Score 4.37
PubTator score by year
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Related Publications
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PMID
Year
Title