Tbio LILRB1 Leukocyte immunoglobulin-like receptor subfamily B member 1

Protein Summary

Description

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NHL6
• A2IXV4
• A8MXT0
• O75024
• O75025
• Q8NHJ9
• Q8NHK0
• LIR-1

Gene Name

• LILRB1

Ensembl ID

• ENST00000448689
• ENSP00000409968
• ENSG00000104972
• ENST00000612636
• ENSP00000479887
• ENSG00000277807
• ENST00000616408
• ENSP00000481700
• ENSG00000274669
• ENST00000617686
• ENSP00000478282
• ENST00000618055
• ENSP00000480365
• ENST00000618681
• ENSP00000479753

Symbol

• ILT2
• LIR1
• MIR7
• ILT2
• LIR1
• MIR7
• PIRB
• CD85J
• ILT-2
• LIR-1
• MIR-7
• PIR-B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.81
biological term	0.77
tissue sample	0.68
cell line	0.56

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Leukocyte Immunoglobulin-like Receptor Subfamily B Member 1

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily B Member 1

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily B Member 1

Protein / ... / Protease Inhibitor / Leukocyte Immunoglobulin-like Receptor Subfamily B Member 1

DTO Classes

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Leukocyte Immunoglobulin-like Receptor Subfamily B Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.88   (req: < 5)

Gene RIFs: 117   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.88   (req: >= 5)

Gene RIFs: 117   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0