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Tbio
LILRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

Protein Summary
Description
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11907092, PubMed:9285411, PubMed:9842885). Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (PubMed:16455647). Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells (PubMed:29262349, PubMed:19304799). Reprograms B cells toward an immune suppressive phenotype (PubMed:24453251). This gene is a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448689
  • ENSP00000409968
  • ENSG00000104972
  • ENST00000612636
  • ENSP00000479887
  • ENSG00000277807
  • ENST00000616408
  • ENSP00000481700
  • ENSG00000274669
  • ENST00000617686
  • ENSP00000478282
  • ENST00000618055
  • ENSP00000480365
  • ENST00000618681
  • ENSP00000479753

Symbol
  • ILT2
  • LIR1
  • MIR7
  • ILT2
  • LIR1
  • MIR7
  • PIRB
  • CD85J
  • ILT-2
  • LIR-1
  • MIR-7
  • PIR-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.81
biological term
0.77
tissue sample
0.68
cell line
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.86   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.86   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
LILRA3
Tdark
p_int:  0.999999994
p_wrong:  6e-9
Data Source:  BioPlex
P13746
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
P05534
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
P16189
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
P16188
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
Q09160
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
P16190
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
P30447
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
P01892
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
P30443
Tbio
Novelty:  0.00270731
Score:  0.996
Data Source:  STRINGDB
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (53)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
8
23
98.8
high density lipoprotein cholesterol measurement
12
8
23
98.8
high density lipoprotein cholesterol measurement
12
8
23
98.8
apolipoprotein A 1 measurement
2
4
4
96.8
apolipoprotein A 1 measurement
2
4
4
96.8
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
23
98.8
high density lipoprotein cholesterol measurement
23
98.8
high density lipoprotein cholesterol measurement
23
98.8
apolipoprotein A 1 measurement
4
96.8
apolipoprotein A 1 measurement
4
96.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 249.86
PubMed score by year
PubTator Score 237.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title