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Tbio
LILRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

Protein Summary
Description
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391736
  • ENSP00000375616
  • ENSG00000186818
  • ENST00000612454
  • ENSP00000479829
  • ENSG00000275730
  • ENST00000614699
  • ENSP00000478542
  • ENST00000621693
  • ENSP00000482234

Symbol
  • ILT3
  • LIR5
  • ILT3
  • LIR5
  • CD85K
  • ILT-3
  • LIR-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
virus perturbation
0.83
cell type or tissue
0.74
tissue sample
0.66
cell line
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.23   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.23   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.999718286
p_ni:  0.000281713
Score:  0.207
Data Source:  BioPlex,STRINGDB
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.99834425
p_ni:  0.00165575
Data Source:  BioPlex
CD47
Tchem
Novelty:  0.00129086
p_int:  0.998048797
p_ni:  0.001951135
p_wrong:  6.8e-8
Score:  0.205
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.981302842
p_ni:  0.018697158
Data Source:  BioPlex
P10314
Tbio
Novelty:  0.00270731
p_int:  0.974773182
p_ni:  0.025226818
Score:  0.918
Data Source:  BioPlex,STRINGDB
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.970569854
p_ni:  0.029430146
Data Source:  BioPlex
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.95296912
p_ni:  0.04703088
Data Source:  BioPlex
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.951170853
p_ni:  0.048815302
p_wrong:  0.000013845
Score:  0.15
Data Source:  BioPlex,STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.907847546
p_ni:  0.092152454
Data Source:  BioPlex
GID4
Tbio
Novelty:  0.05252674
p_int:  0.879163464
p_ni:  0.120836536
Data Source:  BioPlex
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2
2
79.1
apolipoprotein A 1 measurement
1
2
2
79.1
monocyte percentage of leukocytes
1
1
1
39.6
monocyte percentage of leukocytes
1
1
1
39.6
high density lipoprotein cholesterol measurement
1
1
1
34.9
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
79.1
apolipoprotein A 1 measurement
2
79.1
monocyte percentage of leukocytes
1
39.6
monocyte percentage of leukocytes
1
39.6
high density lipoprotein cholesterol measurement
1
34.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leukocyte immunoglobulin like receptor B4
VGNC:11160
450126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leukocyte immunoglobulin like receptor B4
Publication Statistics
PubMed Score 90.23
PubMed score by year
PubTator Score 65.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title