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Tdark
TTLL11
Tubulin polyglutamylase TTLL11

Protein Summary
Description
Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321582
  • ENSP00000321346
  • ENSG00000175764
  • ENST00000373776
  • ENSP00000362881

Symbol
  • C9orf20
  • C9orf20
  • bA244O19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.72
tissue sample
0.67
histone modification site profile
0.64
transcription factor
0.62
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
TTLL12
Tbio
Family:  Enzyme
Novelty:  0.12652318
Score:  0.679
Data Source:  STRINGDB
GLT6D1
Tbio
Family:  Enzyme
Novelty:  0.14285349
Score:  0.665
Data Source:  STRINGDB
CRTC3
Tbio
Novelty:  0.04041516
Score:  0.637
Data Source:  STRINGDB
AGBL4
Tbio
Family:  Enzyme
Novelty:  0.06139701
Score:  0.604
Data Source:  STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
Score:  0.594
Data Source:  STRINGDB
AGTPBP1
Tbio
Family:  Enzyme
Novelty:  0.01925456
Score:  0.588
Data Source:  STRINGDB
FAM83E
Tdark
Novelty:  1.11201089
Score:  0.581
Data Source:  STRINGDB
TMEM214
Tdark
Novelty:  0.32604613
Score:  0.575
Data Source:  STRINGDB
FUT1
Tbio
Family:  Enzyme
Novelty:  0.00597206
Score:  0.549
Data Source:  STRINGDB
AGBL5
Tbio
Family:  Enzyme
Novelty:  0.05735805
Score:  0.548
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3
3
5.8
90.9
mathematical ability
2
1
2
68.6
household income
1
3
3
61.3
intelligence
3
3
2
5.8
52.3
heel bone mineral density
1
2
2
50.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.8
90.9
mathematical ability
2
68.6
household income
3
61.3
intelligence
2
5.8
52.3
heel bone mineral density
2
50.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 11
VGNC:10116
473038
Macaque
tubulin polyglutamylase TTLL11
698836
Mouse
MGI:1921660
74410
Dog
tubulin tyrosine ligase like 11
VGNC:47974
491355
Opossum
tubulin tyrosine ligase like 11
100016416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin tyrosine ligase like 11
Macaque
tubulin polyglutamylase TTLL11
Mouse
Dog
tubulin tyrosine ligase like 11
Opossum
tubulin tyrosine ligase like 11
Publication Statistics
PubMed Score 2.63
PubMed score by year
PubTator Score 0.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title