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Tbio
SVIP
Small VCP/p97-interacting protein

Protein Summary
Description
Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354193
  • ENSP00000346130
  • ENSG00000198168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
virus perturbation
0.83
histone modification site profile
0.73
cellular component
0.69
biological process
0.52


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.15   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.15   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small VCP interacting protein
VGNC:13382
451082
Macaque
small VCP interacting protein
700825
Mouse
MGI:1922994
75744
Rat
RGD:1565432
499157
Dog
small VCP interacting protein
VGNC:52292
100500800
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small VCP interacting protein
Macaque
small VCP interacting protein
Mouse
Rat
Dog
small VCP interacting protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NHG7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (113)
1 – 10 of 113
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
p_int: 0.92279888
p_ni: 0.050548383
p_wrong: 0.026652736
Data Source: BioPlex
GJB7
Tbio
Novelty: 0.12555147
p_int: 0.84623458
p_ni: 0.075749656
p_wrong: 0.078015764
Data Source: BioPlex
MGST3
Tbio
Family: Enzyme
Novelty: 0.02891864
p_int: 0.844980828
p_ni: 0.114139787
p_wrong: 0.040879384
Score: 0.19
Data Source: BioPlex,STRINGDB
CPA5
Tbio
Family: Enzyme
Novelty: 0.0516555
p_int: 0.840621539
p_ni: 0.08248426
p_wrong: 0.076894201
Score: 0.161
Data Source: BioPlex,STRINGDB
DMC1
Tbio
Novelty: 0.05445277
p_int: 0.831045281
p_ni: 0.090749149
p_wrong: 0.078205571
Score: 0.239
Data Source: BioPlex,STRINGDB
DUSP22
Tbio
Family: Enzyme
Novelty: 0.01579003
p_int: 0.829315311
p_ni: 0.078700095
p_wrong: 0.091984595
Data Source: BioPlex
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
p_int: 0.828621784
p_ni: 0.149298211
p_wrong: 0.022080005
Score: 0.175
Data Source: BioPlex,STRINGDB
TMEM185A
Tdark
Novelty: 0.0262898
p_int: 0.803903532
p_ni: 0.107797579
p_wrong: 0.08829889
Data Source: BioPlex
SLC16A14
Tbio
Family: Transporter
Novelty: 0.0669267
p_int: 0.759726687
p_ni: 0.180677751
p_wrong: 0.059595562
Score: 0.269
Data Source: BioPlex,STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.15

PubMed score by year
PubTator Score  5.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer