Tbio ATP6V0E2 V-type proton ATPase subunit e 2

Protein Summary

Description

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles, clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found in plasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and sperm maturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transport H+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodes an isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 [PubMed 17350184]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NHE4
• A2T863
• A2T8L7
• B5MDP5
• J3KQW7
• Q6MZW1
• Q75L47
• Q7Z4R7
• Q8N7I8
• V-ATPase subunit e 2

Gene Name

• ATP6V0E2

Ensembl ID

• ENST00000425642
• ENSP00000396148
• ENSG00000171130
• ENST00000456496
• ENSP00000410220
• ENST00000464662
• ENSP00000475645
• ENST00000471877
• ENSP00000420679
• ENST00000479613
• ENSP00000417939
• ENST00000606024
• ENSP00000475904
• ENST00000615196
• ENSP00000481176
• ENST00000649866
• ENSP00000497146

Symbol

• ATP6V0E2L
• C7orf32
• C7orf32
• ATP6V0E2L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
disease perturbation	0.9
gene perturbation	0.9
cellular component	0.86
small molecule perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase Subunit E 2

Protein / Hydrolase / Phosphatase / Nucleotide Phosphatase / V-type Proton Atpase Subunit E 2

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase Subunit E 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.56   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.56   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0