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Tdark
OR5D18
Olfactory receptor 5D18

Protein Summary
Description
Odorant receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333976
  • ENSP00000335025
  • ENSG00000186119

Symbol
  • OR11-143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.67
cell type or tissue
0.46
protein domain
0.41
molecular function
0.35
pathway
0.32


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
RTP1
Tbio
Novelty:  0.0278378
Score:  0.931
Data Source:  STRINGDB
GNAL
Tbio
Novelty:  0.01757098
Score:  0.912
Data Source:  STRINGDB
RTP2
Tbio
Novelty:  0.05972678
Score:  0.912
Data Source:  STRINGDB
REEP4
Tbio
Novelty:  0.37950931
Score:  0.9
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.9
Data Source:  STRINGDB
REEP5
Tbio
Novelty:  0.00160455
Score:  0.9
Data Source:  STRINGDB
RTP3
Tbio
Novelty:  0.05721596
Score:  0.9
Data Source:  STRINGDB
REEP2
Tbio
Novelty:  0.23897587
Score:  0.9
Data Source:  STRINGDB
REEP3
Tbio
Novelty:  0.19673119
Score:  0.9
Data Source:  STRINGDB
RTP4
Tbio
Novelty:  0.05959975
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
2
2
80.9
apolipoprotein A 1 measurement
1
2
2
68.8
IGF-1 measurement
1
1
1
62.1
body height
2
2
2
49.1
C-reactive protein measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
80.9
apolipoprotein A 1 measurement
2
68.8
IGF-1 measurement
1
62.1
body height
2
49.1
C-reactive protein measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
olfactory receptor family 5 subfamily D member 18
VGNC:13363
466539
Mouse
MGI:2151908
117004
Cow
olfactory receptor, family 5, subfamily D, member 18
515520
Species
Name
OMA
EggNOG
Inparanoid
Chimp
olfactory receptor family 5 subfamily D member 18
Mouse
Cow
olfactory receptor, family 5, subfamily D, member 18
Publication Statistics
PubMed Score 0.54
PubMed score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title