Tdark NPB Neuropeptide B

Protein Classes

DTO Classes

Neuropeptide W/neuropeptide B Receptor / Neuropeptide W/neuropeptide B Receptor Gene / Des-br-neuropeptide B-29 / Des-br-neuropeptide B-23 / Neuropeptide B-23 / Neuropeptide B-29

Protein Summary

Description

May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• Q8NG41
• A0AUX9
• A6NJD6
• B9EJC3

Gene Name

• NPB

Ensembl ID

• ENST00000333383
• ENSP00000332766
• ENSG00000183979

Symbol

• PPL7
• PPNPB
• L7
• PPL7
• PPNPB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.55
tissue	0.55
pathway	0.47
disease	0.41
cell type or tissue	0.39

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.44   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 34   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.44   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	neuropeptide B		714956
Mouse	neuropeptide B	MGI:2387153	208990
Rat	neuropeptide B	RGD:708513	259222
Dog	neuropeptide B	VGNC:43911	100855442
Cow	neuropeptide B	VGNC:32192	280880

Species	Name	OMA	EggNOG	Inparanoid
Macaque	neuropeptide B
Mouse	neuropeptide B
Rat	neuropeptide B
Dog	neuropeptide B
Cow	neuropeptide B

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8NG41-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)

Reactome (7)

KEGG (1)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Peptide ligand-binding receptors	189 targets	R-HSA-375276

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Peptide ligand-binding receptors	189 targets	R-HSA-375276

Gene Ontology Terms (4)

Functions (1)

Components (1)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
G protein-coupled receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (264)

Explore Interacting Targets

1 – 10 of 264

• See Interactions on String-DB

PDP2

Tbio

Family: Enzyme

Novelty: 0.0259516

p_int: 0.999998033

p_ni: 0.000001967

Score: 0.171

Data Source: BioPlex,STRINGDB

ACTA2

Tbio

Novelty: 0.00199354

p_int: 0.999771369

p_ni: 0.000228631

Data Source: BioPlex

AMY1A

Tchem

Family: Enzyme

Novelty: 0.00210045

p_int: 0.999734719

p_ni: 0.000265281

Data Source: BioPlex

MUC7

Tbio

Novelty: 0.00750654

p_int: 0.999733904

p_ni: 0.000220375

p_wrong: 0.000045721

Data Source: BioPlex

IGHA2

Tbio

p_int: 0.999473276

p_ni: 0.000525475

p_wrong: 0.000001249

Data Source: BioPlex

CST2

Tbio

Novelty: 0.02114441

p_int: 0.999364638

p_ni: 0.000635361

p_wrong: 2e-9

Data Source: BioPlex

PIGR

Tbio

Novelty: 0.0025812

p_int: 0.999186358

p_ni: 0.000813637

p_wrong: 5e-9

Data Source: BioPlex

IL16

Tbio

Novelty: 0.0023276

p_int: 0.997713513

p_ni: 0.000259679

p_wrong: 0.002026808

Score: 0.161

Data Source: BioPlex,STRINGDB

ZG16B

Tbio

Novelty: 0.08792924

p_int: 0.995732618

p_ni: 0.004267382

Data Source: BioPlex

UBR1

Tbio

Family: Enzyme

Novelty: 0.00998888

p_int: 0.995124853

p_ni: 0.004875147

Data Source: BioPlex

Publication Statistics

PubMed Score  105.44

PubMed score by year

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PubTator Score  128.2

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Neuropeptide
Reference proteome
Secreted
Signal

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
growth/size/body region phenotype
integument phenotype