Protein Summary
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
- ENST00000333383
- ENSP00000332766
- ENSG00000183979
- PPL7
- PPNPB
- L7
- PPL7
- PPNPB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.55 | ||
tissue | 0.55 | ||
pathway | 0.47 | ||
disease | 0.41 | ||
cell type or tissue | 0.39 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.84 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 34 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.84 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 34 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (264)
PDP2
Family: Enzyme
Novelty: 0.0259516
p_int: 0.999998033
p_ni: 0.000001967
Score: 0.171
Data Source: BioPlex,STRINGDB
AMY1A
Family: Enzyme
Novelty: 0.00210045
p_int: 0.999734719
p_ni: 0.000265281
Data Source: BioPlex
MUC7
Novelty: 0.00750654
p_int: 0.999733904
p_ni: 0.000220375
p_wrong: 0.000045721
Data Source: BioPlex
IL16
Novelty: 0.0023276
p_int: 0.997713513
p_ni: 0.000259679
p_wrong: 0.002026808
Score: 0.161
Data Source: BioPlex,STRINGDB
UBR1
Family: Enzyme
Novelty: 0.00998888
p_int: 0.995124853
p_ni: 0.004875147
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (7)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vital capacity | 1 | 1 | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 2 | 3 | 3 | 58.3 | |||||
BMI-adjusted hip circumference | 1 | 2 | 2 | 55.8 | |||||
birth weight | 2 | 2 | 2 | 55.2 | |||||
hematocrit | 2 | 2 | 2 | 55.2 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vital capacity | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 3 | 58.3 | |||||
BMI-adjusted hip circumference | 2 | 55.8 | |||||
birth weight | 2 | 55.2 | |||||
hematocrit | 2 | 55.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | neuropeptide B | 714956 | ||||||
Mouse | MGI:2387153 | 208990 | ||||||
Rat | RGD:708513 | 259222 | ||||||
Dog | neuropeptide B | VGNC:43911 | 100855442 | |||||
Cow | neuropeptide B | VGNC:32192 | 280880 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | neuropeptide B | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuropeptide B | |||||
Cow | neuropeptide B | |||||
Publication Statistics
PubMed Score 106.84
PubMed score by year
PubTator Score 128.20
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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