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Tdark
NPB
Neuropeptide B

Protein Summary
Description
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333383
  • ENSP00000332766
  • ENSG00000183979

Symbol
  • PPL7
  • PPNPB
  • L7
  • PPL7
  • PPNPB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.55
tissue
0.55
pathway
0.47
disease
0.41
cell type or tissue
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0