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Tdark
NPB
Neuropeptide B

Protein Summary
Description
May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333383
  • ENSP00000332766
  • ENSG00000183979

Symbol
  • PPL7
  • PPNPB
  • L7
  • PPL7
  • PPNPB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.55
tissue
0.55
pathway
0.47
disease
0.41
cell type or tissue
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (264)
PDP2
Tbio
Family:  Enzyme
Novelty:  0.0259516
p_int:  0.999998033
p_ni:  0.000001967
Score:  0.171
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.999771369
p_ni:  0.000228631
Data Source:  BioPlex
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.999734719
p_ni:  0.000265281
Data Source:  BioPlex
MUC7
Tbio
Novelty:  0.00750654
p_int:  0.999733904
p_ni:  0.000220375
p_wrong:  0.000045721
Data Source:  BioPlex
IGHA2
Tbio
p_int:  0.999473276
p_ni:  0.000525475
p_wrong:  0.000001249
Data Source:  BioPlex
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999364638
p_ni:  0.000635361
p_wrong:  2e-9
Data Source:  BioPlex
PIGR
Tbio
Novelty:  0.0025812
p_int:  0.999186358
p_ni:  0.000813637
p_wrong:  5e-9
Data Source:  BioPlex
IL16
Tbio
Novelty:  0.0023276
p_int:  0.997713513
p_ni:  0.000259679
p_wrong:  0.002026808
Score:  0.161
Data Source:  BioPlex,STRINGDB
ZG16B
Tbio
Novelty:  0.08792924
p_int:  0.995732618
p_ni:  0.004267382
Data Source:  BioPlex
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.995124853
p_ni:  0.004875147
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
73.2
BMI-adjusted waist-hip ratio
2
3
3
58.3
BMI-adjusted hip circumference
1
2
2
55.8
birth weight
2
2
2
55.2
hematocrit
2
2
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
73.2
BMI-adjusted waist-hip ratio
3
58.3
BMI-adjusted hip circumference
2
55.8
birth weight
2
55.2
hematocrit
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neuropeptide B
714956
Mouse
MGI:2387153
208990
Rat
RGD:708513
259222
Dog
neuropeptide B
VGNC:43911
100855442
Cow
neuropeptide B
VGNC:32192
280880
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neuropeptide B
Mouse
Rat
Dog
neuropeptide B
Cow
neuropeptide B
Publication Statistics
PubMed Score 106.84
PubMed score by year
PubTator Score 128.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title