You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DEFB105A
Beta-defensin 105

Protein Summary
Description
Has antibacterial activity. Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334773
  • ENSP00000334330
  • ENSG00000186562
  • ENST00000335510
  • ENSP00000335281
  • ENSG00000186599
  • ENST00000611610
  • ENSP00000482176
  • ENSG00000274729
  • ENST00000644948
  • ENSP00000496561
  • ENSG00000285015

Symbol
  • BD5
  • DEFB105
  • DEFB5
  • BD-5
  • DEFB-5
  • DEFB105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.54
disease
0.34
biological term
0.33
tissue
0.33
small molecule perturbation
0.15


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NG35-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (18)
1 – 10 of 18
DEFB106A
Tbio
Novelty:  0.0474196
Score:  0.864
Data Source:  STRINGDB
DEFB107A
Tdark
Novelty:  0.20848172
Score:  0.832
Data Source:  STRINGDB
DEFB103A
Tbio
Novelty:  0.00328986
Score:  0.773
Data Source:  STRINGDB
DEFB104A
Tbio
Novelty:  0.0468791
Score:  0.768
Data Source:  STRINGDB
DEFB108B
Tdark
Novelty:  0.4704814
Score:  0.767
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.718
Data Source:  STRINGDB
PRR23D1
Tdark
Novelty:  14.34482759
Score:  0.634
Data Source:  STRINGDB
DEFB126
Tbio
Novelty:  0.05538355
Score:  0.624
Data Source:  STRINGDB
USP17L1
Tdark
Family:  Enzyme
Novelty:  2.66694594
Score:  0.517
Data Source:  STRINGDB
PRR23A
Tdark
Novelty:  15.74603175
Score:  0.502
Data Source:  STRINGDB
Publication Statistics
PubMed Score  26.66

PubMed score by year
PubTator Score  11.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer