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Tbio
PJA1
E3 ubiquitin-protein ligase Praja-1

Protein Summary
Description
Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361478
  • ENSP00000355014
  • ENSG00000181191
  • ENST00000374571
  • ENSP00000363699
  • ENST00000374583
  • ENSP00000363711
  • ENST00000374584
  • ENSP00000363712

Symbol
  • RNF70
  • RNF70
  • PRAJA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.8
disease perturbation
0.79
histone modification site profile
0.62
tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (306)
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.999221979
p_ni:  0.000778021
Score:  0.258
Data Source:  BioPlex,STRINGDB
SMC5
Tbio
Novelty:  0.008623
p_int:  0.996305202
p_ni:  0.003694798
Score:  0.763
Data Source:  BioPlex,STRINGDB
SMC6
Tbio
Novelty:  0.02450073
p_int:  0.990594071
p_ni:  0.009405929
Score:  0.639
Data Source:  BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty:  0.45550673
p_int:  0.986767746
p_ni:  0.013232248
p_wrong:  6e-9
Score:  0.79
Data Source:  BioPlex,STRINGDB
NSMCE3
Tbio
Novelty:  0.04335295
p_int:  0.985249447
p_ni:  0.014750453
p_wrong:  1e-7
Score:  0.782
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.963312816
p_ni:  0.036687182
p_wrong:  2e-9
Data Source:  BioPlex
CHRAC1
Tbio
Novelty:  0.17492099
p_int:  0.956803603
p_ni:  0.042878735
p_wrong:  0.000317662
Score:  0.224
Data Source:  BioPlex,STRINGDB
CTAG2
Tbio
Novelty:  0.02983879
p_int:  0.901212998
p_ni:  0.098786944
p_wrong:  5.8e-8
Data Source:  BioPlex
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.897014401
p_ni:  0.102985599
Score:  0.221
Data Source:  BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.895547978
p_ni:  0.104452022
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
68.5
platelet count
1
1
1
61
platelet crit
1
1
1
52.7
body mass index
1
1
1
42.3
birth weight
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
68.5
platelet count
1
61
platelet crit
1
52.7
body mass index
1
42.3
birth weight
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 19.12
PubMed score by year
PubTator Score 5.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title