Tbio TSPAN14 Tetraspanin-14

Protein Summary

Description

Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).

Uniprot Accession IDs

• Q8NG11
• A6NHE1
• B4DHY6
• D3DWD7
• D3DWD8
• Q567U7
• Q9BU34
• Q9H0U1
• Tspan-14

Gene Name

• TSPAN14

Ensembl ID

• ENST00000372156
• ENSP00000361229
• ENSG00000108219
• ENST00000372158
• ENSP00000361231
• ENST00000372164
• ENSP00000361237
• ENST00000429989
• ENSP00000396270
• ENST00000481124
• ENSP00000418195
• ENST00000616406
• ENSP00000480263

Symbol

• TM4SF14
• TM4SF14
• DC-TM4F2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor perturbation	0.91
kinase perturbation	0.71
transcription factor binding site profile	0.7
microRNA	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.37   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.37   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0