Protein Summary
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).
- ENST00000372156
- ENSP00000361229
- ENSG00000108219
- ENST00000372158
- ENSP00000361231
- ENST00000372164
- ENSP00000361237
- ENST00000429989
- ENSP00000396270
- ENST00000481124
- ENSP00000418195
- ENST00000616406
- ENSP00000480263
- TM4SF14
- TM4SF14
- DC-TM4F2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.71 | ||
transcription factor binding site profile | 0.7 | ||
microRNA | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.37 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 54 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.37 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 54 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0