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Tdark
TSPAN14
Tetraspanin-14

Protein Summary
Description
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372156
  • ENSP00000361229
  • ENSG00000108219
  • ENST00000372158
  • ENSP00000361231
  • ENST00000372164
  • ENSP00000361237
  • ENST00000429989
  • ENSP00000396270
  • ENST00000481124
  • ENSP00000418195
  • ENST00000616406
  • ENSP00000480263

Symbol
  • TM4SF14
  • TM4SF14
  • DC-TM4F2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.91
kinase perturbation
0.71
transcription factor binding site profile
0.7
microRNA
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
77
monocyte count
1
1
1
70.5
1
1
0
1.1
69.8
myeloid white cell count
1
1
1
68.8
hematocrit
2
2
2
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
77
monocyte count
1
70.5
0
1.1
69.8
myeloid white cell count
1
68.8
hematocrit
2
67.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 14
VGNC:12514
741182
Macaque
tetraspanin 14
706027
Mouse
MGI:1196325
52588
Rat
RGD:1305714
306324
Dog
tetraspanin 14
VGNC:47914
610573
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 14
Macaque
tetraspanin 14
Mouse
Rat
Dog
tetraspanin 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NG11-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (141)
1 – 10 of 141
ADAM10
Tchem
Family:  Enzyme
Novelty:  0.00160129
Score:  0.982
Data Source:  Reactome,STRINGDB
PTPRJ
Tbio
Family:  Enzyme
Novelty:  0.00786921
Score:  0.932
Data Source:  STRINGDB
UBR4
Tbio
Family:  Enzyme
Novelty:  0.03924839
Score:  0.926
Data Source:  STRINGDB
STOM
Tbio
Novelty:  0.00459891
Score:  0.926
Data Source:  STRINGDB
CD36
Tbio
Novelty:  0.00140825
Score:  0.917
Data Source:  STRINGDB
CD59
Tbio
Novelty:  0.0008352
Score:  0.91
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.908
Data Source:  STRINGDB
CD53
Tbio
Novelty:  0.01722633
Score:  0.908
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.906
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.906
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.64

PubMed score by year
PubTator Score  1.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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