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Tbio
HELB
DNA helicase B

Protein Summary
Description
5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247815
  • ENSP00000247815
  • ENSG00000127311
  • ENST00000440906
  • ENSP00000396955
  • ENST00000545134
  • ENSP00000443287

Symbol
  • DHB
  • hDHB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
histone modification site profile
0.78
virus perturbation
0.72
transcription factor perturbation
0.68
transcription factor binding site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
5
4
5
87.8
basophil percentage of leukocytes
2
2
2
81
age at menopause
1
1
1
80.4
basophil percentage of granulocytes
1
1
1
68.3
response to ketamine
1
1
0
51.6
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
5
87.8
basophil percentage of leukocytes
2
81
age at menopause
1
80.4
basophil percentage of granulocytes
1
68.3
response to ketamine
0
51.6
15.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA helicase B
VGNC:8420
452058
Macaque
DNA helicase B
717860
Mouse
MGI:2152895
117599
Rat
RGD:1560103
500837
Dog
DNA helicase B
VGNC:41648
608595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA helicase B
Macaque
DNA helicase B
Mouse
Rat
Dog
DNA helicase B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NG08-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999999998
p_ni:  2e-9
Score:  0.364
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.998445117
p_ni:  0.000001599
p_wrong:  0.001553283
Score:  0.188
Data Source:  BioPlex,STRINGDB
RPA1
Tchem
Novelty:  0.00212665
Score:  0.994
Data Source:  STRINGDB
RPA3
Tbio
Novelty:  0.00887858
Score:  0.993
Data Source:  STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.993
Data Source:  STRINGDB
ARMC1
Tbio
Novelty:  0.02018109
Score:  0.794
Data Source:  STRINGDB
LLPH
Tbio
Novelty:  0.19149323
Score:  0.724
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.666
Data Source:  STRINGDB
DESI2
Tbio
Family:  Enzyme
Novelty:  0.026329
Score:  0.653
Data Source:  STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
Score:  0.636
Data Source:  STRINGDB
Publication Statistics
PubMed Score  49.71

PubMed score by year
PubTator Score  25.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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