Tbio HELB DNA helicase B

Protein Summary

Description

5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates (PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress (PubMed:22194613). This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q8NG08
• A8K4C9
• Q4G0T2
• Q9H7L5
• hDHB

Gene Name

• HELB

Ensembl ID

• ENST00000247815
• ENSP00000247815
• ENSG00000127311
• ENST00000440906
• ENSP00000396955
• ENST00000545134
• ENSP00000443287

Symbol

• DHB
• hDHB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
histone modification site profile	0.78
virus perturbation	0.72
transcription factor perturbation	0.68
transcription factor binding site profile	0.62

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Dna Helicase B

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Dna Helicase B

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Dna Helicase B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.47   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.47   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0