Tbio TNIP2 TNFAIP3-interacting protein 2

Protein Summary

Description

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q8NFZ5
• B1AKS4
• B3KTY8
• D3DVQ9
• Q7L5L2
• Q9BQR6
• Q9H682

Gene Name

• TNIP2

Ensembl ID

• ENST00000315423
• ENSP00000321203
• ENSG00000168884
• ENST00000510267
• ENSP00000427613

Symbol

• ABIN2
• FLIP1
• KLIP
• ABIN2
• FLIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
drug perturbation	0.87
kinase perturbation	0.81
disease perturbation	0.74
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.51   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.51   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0