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Tbio
SEMA6D
Semaphorin-6D

Protein Summary
Description
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316364
  • ENSP00000324857
  • ENSG00000137872
  • ENST00000354744
  • ENSP00000346786
  • ENST00000355997
  • ENSP00000348276
  • ENST00000358066
  • ENSP00000350770
  • ENST00000389425
  • ENSP00000374076
  • ENST00000389428
  • ENSP00000374079
  • ENST00000536845
  • ENSP00000446152
  • ENST00000558014
  • ENSP00000452815
  • ENST00000558816
  • ENSP00000453661

Symbol
  • KIAA1479
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
microRNA
0.89
virus perturbation
0.83
protein domain
0.73
transcription factor
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.949452359
p_ni:  0.050544203
p_wrong:  0.000003439
Score:  0.222
Data Source:  BioPlex,STRINGDB
PLXNA1
Tbio
Novelty:  0.01195083
Score:  0.976
Data Source:  Reactome,STRINGDB
PLXNB3
Tbio
Novelty:  0.02948198
Score:  0.944
Data Source:  STRINGDB
TREM2
Tbio
Novelty:  0.00228007
Score:  0.937
Data Source:  Reactome,STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.935
Data Source:  Reactome,STRINGDB
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.915
Data Source:  STRINGDB
PLXNC1
Tbio
Novelty:  0.02179837
Score:  0.912
Data Source:  STRINGDB
NRP2
Tbio
Novelty:  0.00764179
Score:  0.852
Data Source:  STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.851
Data Source:  STRINGDB
EFNB3
Tbio
Novelty:  0.0120367
Score:  0.813
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
4
4
94.5
smoking initiation
3
3
3
85.8
self reported educational attainment
4
7
7
5.6
84.7
smoking behavior
1
3
3
79.1
3
4
1
5.5
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
4
94.5
smoking initiation
3
85.8
self reported educational attainment
7
5.6
84.7
smoking behavior
3
79.1
1
5.5
74.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 6D
VGNC:6587
467674
Macaque
semaphorin 6D
713885
Mouse
MGI:2387661
214968
Rat
RGD:1310910
311384
Dog
semaphorin 6D
VGNC:46004
100855988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 6D
Macaque
semaphorin 6D
Mouse
Rat
Dog
semaphorin 6D
Publication Statistics
PubMed Score 63.37
PubMed score by year
PubTator Score 11.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title