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Tbio
STXBP6
Syntaxin-binding protein 6

Protein Summary
Description
Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis. STXBP6 binds components of the SNARE complex (see MIM 603215) and may be involved in regulating SNARE complex formation (Scales et al., 2002 [PubMed 12145319]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323944
  • ENSP00000324302
  • ENSG00000168952
  • ENST00000396700
  • ENSP00000379928
  • ENST00000419632
  • ENSP00000397212
  • ENST00000546511
  • ENSP00000449536
  • ENST00000548369
  • ENSP00000447655
  • ENST00000550887
  • ENSP00000449379

Symbol
  • amisyn
  • HSPC156
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.76
trait
0.75
histone modification site profile
0.73
transcription factor
0.69
disease
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.63   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.63   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (82)
1 – 10 of 82
ALS2
Tbio
Novelty:  0.0072324
p_int:  0.999999851
p_ni:  3.8e-8
p_wrong:  1.12e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999996561
p_ni:  0.000003439
p_wrong:  1e-9
Score:  0.746
Data Source:  BioPlex,STRINGDB
STX1A
Tbio
Novelty:  0.00087207
p_int:  0.999967631
p_ni:  0.000032362
p_wrong:  7e-9
Score:  0.592
Data Source:  BioPlex,STRINGDB
STX3
Tbio
Novelty:  0.01055819
p_int:  0.999897963
p_ni:  0.000102028
p_wrong:  9e-9
Score:  0.872
Data Source:  BioPlex,STRINGDB
STX4
Tbio
Novelty:  0.00831588
p_int:  0.999062595
p_ni:  0.000937404
Score:  0.942
Data Source:  BioPlex,STRINGDB
NAPG
Tbio
Novelty:  0.02295985
p_int:  0.998563973
p_ni:  0.001410239
p_wrong:  0.000025789
Score:  0.823
Data Source:  BioPlex,STRINGDB
STX8
Tbio
Novelty:  0.01083752
p_int:  0.996086284
p_ni:  0.003913716
Score:  0.732
Data Source:  BioPlex,STRINGDB
VTI1B
Tbio
Novelty:  0.00955467
p_int:  0.995648046
p_ni:  0.004351954
Score:  0.591
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.991974623
p_ni:  0.008025377
Score:  0.66
Data Source:  BioPlex,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
p_int:  0.990202658
p_ni:  0.009797328
p_wrong:  1.3e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
4
3
4
96
monocyte count
4
2
4
94.9
myeloid white cell count
3
2
3
94.4
neutrophil count
4
2
4
93.8
lymphocyte percentage of leukocytes
2
2
2
90.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
4
96
monocyte count
4
94.9
myeloid white cell count
3
94.4
neutrophil count
4
93.8
lymphocyte percentage of leukocytes
2
90.6
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 6
VGNC:6773
452826
Mouse
MGI:2384963
217517
Rat
RGD:1306117
362734
Dog
syntaxin binding protein 6
VGNC:46965
608615
Horse
syntaxin binding protein 6
VGNC:23738
100053091
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 6
Mouse
Rat
Dog
syntaxin binding protein 6
Horse
syntaxin binding protein 6
Publication Statistics
PubMed Score 9.63
PubMed score by year
PubTator Score 4.22
PubTator score by year