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Tbio
MYRIP
Rab effector MyRIP

Protein Summary
Description
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302541
  • ENSP00000301972
  • ENSG00000170011
  • ENST00000396217
  • ENSP00000379519
  • ENST00000425621
  • ENSP00000389323
  • ENST00000444716
  • ENSP00000398665
  • ENST00000458292
  • ENSP00000413392
  • ENST00000539167
  • ENSP00000438297

Symbol
  • SLAC2C
  • SLAC2C
  • SLAC2-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
kinase perturbation
0.81
microRNA
0.71
PubMedID
0.71
histone modification site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.43   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (41)
1 – 10 of 41
MYO5A
Tbio
Novelty:  0.00373224
Score:  0.993
Data Source:  Reactome,STRINGDB
RAB27A
Tchem
Family:  Enzyme
Novelty:  0.00369416
Score:  0.992
Data Source:  Reactome,STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.922
Data Source:  STRINGDB
MYO7A
Tbio
Novelty:  0.00314435
Score:  0.875
Data Source:  STRINGDB
RAB27B
Tbio
Family:  Enzyme
Novelty:  0.01530218
Score:  0.81
Data Source:  STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
Score:  0.808
Data Source:  STRINGDB
EXOC4
Tbio
Novelty:  0.01636648
Score:  0.806
Data Source:  STRINGDB
SYTL1
Tbio
Novelty:  0.09070371
Score:  0.716
Data Source:  STRINGDB
CADM2
Tbio
Novelty:  0.02563959
Score:  0.669
Data Source:  STRINGDB
RIMBP2
Tdark
Novelty:  0.06169893
Score:  0.663
Data Source:  STRINGDB
Pathways (4)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Peptide hormone metabolism
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin VIIA and Rab interacting protein
VGNC:2435
470796
Macaque
myosin VIIA and Rab interacting protein
717173
Mouse
MGI:2384407
245049
Rat
RGD:727731
360034
Dog
myosin VIIA and Rab interacting protein
VGNC:43589
485603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin VIIA and Rab interacting protein
Macaque
myosin VIIA and Rab interacting protein
Mouse
Rat
Dog
myosin VIIA and Rab interacting protein
Publication Statistics
PubMed Score 15.43
PubMed score by year
PubTator Score 10.37
PubTator score by year