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Tbio
COL22A1
Collagen alpha-1(XXII) chain

Protein Summary
Description
Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. This gene encodes member of the collagen family which is thought to contribute to the stabilization of myotendinous junctions and strengthen skeletal muscle attachments during contractile activity. It belongs to the fibril-associated collagens with interrupted triple helix (FACIT) subset of the collagen superfamily, which associate with collagen fibers through their C-terminal collagenous domains and mediate protein-protein interactions through their N-terminal noncollagenous domains. The encoded protein is deposited in the basement membrane zone of the myotendinous junction which is present only at the tissue junctions of muscles, tendons, the heart, articular cartilage, and skin. A knockdown of the orthologous zebrafish gene induces a muscular dystrophy by disruption of the myotendinous junction. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303045
  • ENSP00000303153
  • ENSG00000169436
  • ENST00000435777
  • ENSP00000387655
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
cell line
0.62
protein domain
0.58
disease
0.55
tissue sample
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.5   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.5   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal break
2
1
0
1.1
46.1
4
1
1
1.2
46.1
gut microbiome measurement
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal break
0
1.1
46.1
1
1.2
46.1
gut microbiome measurement
1
27.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1916950
69700
Rat
RGD:1309081
315071
Dog
collagen type XXII alpha 1 chain
VGNC:39468
482056
Horse
collagen type XXII alpha 1 chain
VGNC:16733
100069427
Cow
collagen type XXII alpha 1 chain
VGNC:27563
521058
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
collagen type XXII alpha 1 chain
Horse
collagen type XXII alpha 1 chain
Cow
collagen type XXII alpha 1 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NFW1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (69)
1 – 10 of 69
COL12A1
Tbio
Novelty:  0.0239421
Score:  0.931
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.927
Data Source:  STRINGDB
COL11A2
Tbio
Novelty:  0.00923441
Score:  0.926
Data Source:  STRINGDB
COL28A1
Tdark
Novelty:  0.95671561
Score:  0.923
Data Source:  STRINGDB
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.922
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.921
Data Source:  STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
Score:  0.92
Data Source:  STRINGDB
COL5A3
Tbio
Novelty:  0.06365591
Score:  0.92
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.92
Data Source:  STRINGDB
COL4A4
Tbio
Novelty:  0.00833684
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.50

PubMed score by year
PubTator Score  4.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer