Tbio COL22A1 Collagen alpha-1(XXII) chain

Protein Summary

Description

Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. This gene encodes member of the collagen family which is thought to contribute to the stabilization of myotendinous junctions and strengthen skeletal muscle attachments during contractile activity. It belongs to the fibril-associated collagens with interrupted triple helix (FACIT) subset of the collagen superfamily, which associate with collagen fibers through their C-terminal collagenous domains and mediate protein-protein interactions through their N-terminal noncollagenous domains. The encoded protein is deposited in the basement membrane zone of the myotendinous junction which is present only at the tissue junctions of muscles, tendons, the heart, articular cartilage, and skin. A knockdown of the orthologous zebrafish gene induces a muscular dystrophy by disruption of the myotendinous junction. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q8NFW1
• B7ZMH0
• C9K0G4
• Q8IVT9

Gene Name

• COL22A1

Ensembl ID

• ENST00000303045
• ENSP00000303153
• ENSG00000169436
• ENST00000435777
• ENSP00000387655

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
cell line	0.62
protein domain	0.58
disease	0.55
tissue sample	0.54

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Collagen Alpha-1(xxii) Chain

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Structural Protein / Collagen Alpha-1(xxii) Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.59   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.59   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0