Tbio IPMK Inositol polyphosphate multikinase

Protein Summary

Description

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12027805, PubMed:12223481). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q8NFU5

Gene Name

• IPMK

Ensembl ID

• ENST00000373935
• ENSP00000363046
• ENSG00000151151

Symbol

• IMPK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
molecular function	0.94
histone modification site profile	0.87
transcription factor binding site profile	0.87
microRNA	0.69

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Inositol Polyphosphate Multikinase

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Inositol Phosphokinase (Ipk) Family / Inositol Polyphosphate Multikinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.77   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.77   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0