Tbio IPMK Inositol polyphosphate multikinase

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Inositol Polyphosphate Multikinase

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Inositol Phosphokinase (Ipk) Family / Inositol Polyphosphate Multikinase

Protein Summary

Description

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12027805, PubMed:12223481). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q8NFU5

Gene Name

• IPMK

Ensembl ID

• ENST00000373935
• ENSP00000363046
• ENSG00000151151

Symbol

• IMPK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
molecular function	0.94
histone modification site profile	0.87
transcription factor binding site profile	0.87
microRNA	0.69

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.03   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.03   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	2	2	0	1.1	67.8
mitochondrial DNA measurement	EFO_0006312	1	1	1		54.4
inflammatory bowel disease	EFO_0003767	1	1	0	1.1	26.6
monocyte percentage of leukocytes	EFO_0007989	1	1	1		11.3
gut microbiome measurement	EFO_0007874	1	1	1		1.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	0	1.1	67.8
mitochondrial DNA measurement	EFO_0006312	1		54.4
inflammatory bowel disease	EFO_0003767	0	1.1	26.6
monocyte percentage of leukocytes	EFO_0007989	1		11.3
gut microbiome measurement	EFO_0007874	1		1.5

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	inositol polyphosphate multikinase	VGNC:5486	450471
Mouse	inositol polyphosphate multikinase	MGI:1916968	69718
Rat	inositol polyphosphate multikinase	RGD:620954	171458
Horse	inositol polyphosphate multikinase	VGNC:19103	100072153
Cow	inositol polyphosphate multikinase	VGNC:30240	615135

Species	Name	OMA	EggNOG	Inparanoid
Chimp	inositol polyphosphate multikinase
Mouse	inositol polyphosphate multikinase
Rat	inositol polyphosphate multikinase
Horse	inositol polyphosphate multikinase
Cow	inositol polyphosphate multikinase

Protein Structure (4 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NFU5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (15)

Reactome (3)

KEGG (3)

PathwayCommons (9)

Inositol phosphate metabolism (R-HSA-1483249)

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Find Similar Targets

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Inositol phosphate metabolism	48 targets	R-HSA-1483249
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Synthesis of IPs in the nucleus	4 targets	R-HSA-1855191

Name	Explore in Pharos	Explore in Source
Inositol phosphate metabolism	48 targets	R-HSA-1483249
Metabolism	2112 targets	R-HSA-1430728
Synthesis of IPs in the nucleus	4 targets	R-HSA-1855191

Gene Ontology Terms (12)

Functions (6)

Components (3)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
inositol tetrakisphosphate 6-kinase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
inositol tetrakisphosphate 3-kinase activity	Traceable Author Statement (TAS)	Reactome
inositol tetrakisphosphate 5-kinase activity	Traceable Author Statement (TAS)	Reactome
inositol-1,4,5-trisphosphate 3-kinase activity	Traceable Author Statement (TAS)	Reactome
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
inositol-1,4,5-trisphosphate 6-kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

IPPK

Tbio

Family:  Enzyme

Novelty:  0.02169701

Score:  0.98

Data Source:  STRINGDB

ITPK1

Tbio

Family:  Kinase

Novelty:  0.02790263

Score:  0.977

Data Source:  STRINGDB

PPIP5K1

Tbio

Family:  Enzyme

Novelty:  0.01175655

Score:  0.975

Data Source:  STRINGDB

ITPKA

Tchem

Family:  Kinase

Novelty:  0.02901348

Score:  0.964

Data Source:  STRINGDB

ITPKB

Tchem

Family:  Kinase

Novelty:  0.02397335

Score:  0.963

Data Source:  STRINGDB

ITPKC

Tchem

Family:  Kinase

Novelty:  0.03063007

Score:  0.959

Data Source:  STRINGDB

INPP5A

Tchem

Family:  Enzyme

Novelty:  0.03249263

Score:  0.952

Data Source:  STRINGDB

PTEN

Tchem

Family:  Enzyme

Novelty:  0.00013818

Score:  0.951

Data Source:  STRINGDB

PPIP5K2

Tchem

Family:  Enzyme

Novelty:  0.0284462

Score:  0.942

Data Source:  STRINGDB

PLCB1

Tbio

Family:  Enzyme

Novelty:  0.00269771

Score:  0.94

Data Source:  STRINGDB

Publication Statistics

PubMed Score  71.03

PubMed score by year

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PubTator Score  27.87

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
Crohn's disease
gut microbiome measurement
inflammatory bowel disease
mitochondrial DNA measurement
monocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

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embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype