IPMK
Inositol polyphosphate multikinase
Protein Summary
Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12027805, PubMed:12223481). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610). This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located o ...more
- ENST00000373935
- ENSP00000363046
- ENSG00000151151
- IMPK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
molecular function | 0.94 | ||
histone modification site profile | 0.87 | ||
transcription factor binding site profile | 0.87 | ||
microRNA | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.03 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 177 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 71.03 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 177 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
Nearest Tclin Targets (5)
Upstream (3)
Downstream (2)
1 – 3 of 3
Pathways (15)
Reactome (3)
KEGG (3)
PathwayCommons (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Inositol phosphate metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Synthesis of IPs in the nucleus | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Inositol phosphate metabolism | ||||
Metabolism | ||||
Synthesis of IPs in the nucleus | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (6)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 67.8 | |||||
mitochondrial DNA measurement | 1 | 1 | 1 | 54.4 | |||||
1 | 1 | 0 | 1.1 | 26.6 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 11.3 | |||||
gut microbiome measurement | 1 | 1 | 1 | 1.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 67.8 | |||||
mitochondrial DNA measurement | 1 | 54.4 | |||||
0 | 1.1 | 26.6 | |||||
monocyte percentage of leukocytes | 1 | 11.3 | |||||
gut microbiome measurement | 1 | 1.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate multikinase | VGNC:5486 | 450471 | |||||
Mouse | MGI:1916968 | 69718 | ||||||
Rat | RGD:620954 | 171458 | ||||||
Horse | inositol polyphosphate multikinase | VGNC:19103 | 100072153 | |||||
Cow | inositol polyphosphate multikinase | VGNC:30240 | 615135 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | inositol polyphosphate multikinase | |||||
Mouse | ||||||
Rat | ||||||
Horse | inositol polyphosphate multikinase | |||||
Cow | inositol polyphosphate multikinase | |||||
Publication Statistics
PubMed Score 71.03
PubMed score by year
PubTator Score 27.87
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (28)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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