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Tbio
FDCSP
Follicular dendritic cell secreted peptide

Protein Summary
Description
Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells. This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317987
  • ENSP00000318437
  • ENSG00000181617

Symbol
  • C4orf7
  • C4orf7
  • FDC-SP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.48
tissue
0.46
virus perturbation
0.45
biological term
0.37
PubMedID
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.21   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.21   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (9)
ODAM
Tbio
Novelty:  0.01922413
Score:  0.677
Data Source:  STRINGDB
C4orf36
Tdark
Novelty:  18
Score:  0.63
Data Source:  STRINGDB
PRR27
Tdark
Novelty:  2.26243094
Score:  0.572
Data Source:  STRINGDB
STATH
Tbio
Novelty:  0.00486778
Score:  0.535
Data Source:  STRINGDB
CFAP299
Tdark
Novelty:  1.357076
Score:  0.491
Data Source:  STRINGDB
CXCL2
Tbio
Novelty:  0.00201175
Score:  0.469
Data Source:  STRINGDB
CXCL13
Tbio
Novelty:  0.00118688
Score:  0.447
Data Source:  STRINGDB
AMTN
Tbio
Novelty:  0.02514528
Score:  0.445
Data Source:  STRINGDB
CD40LG
Tbio
Novelty:  0.00032058
Score:  0.441
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
follicular dendritic cell secreted protein
742341
Macaque
follicular dendritic cell secreted protein
707784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
follicular dendritic cell secreted protein
Macaque
follicular dendritic cell secreted protein
Publication Statistics
PubMed Score 21.21
PubMed score by year
PubTator Score 11.06
PubTator score by year
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Related Publications
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PMID
Year
Title