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Tdark
SPTSSB
Serine palmitoyltransferase small subunit B

Protein Summary
Description
Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. May play a role in signal transduction. Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359175
  • ENSP00000352097
  • ENSG00000196542
  • ENST00000497137
  • ENSP00000420115
  • ENST00000620149
  • ENSP00000480827

Symbol
  • ADMP
  • C3orf57
  • SSSPTB
  • ADMP
  • SSSPTB
  • C3orf57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
cell type or tissue
0.67
microRNA
0.6
gene perturbation
0.56
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
SPTLC3
Tbio
Family:  Enzyme
Novelty:  0.03671571
Score:  0.993
Data Source:  Reactome,STRINGDB
SPTLC1
Tchem
Family:  Enzyme
Novelty:  0.00639691
Score:  0.993
Data Source:  Reactome,STRINGDB
SPTLC2
Tchem
Family:  Enzyme
Novelty:  0.01236952
Score:  0.993
Data Source:  Reactome,STRINGDB
ORMDL3
Tbio
Novelty:  0.00958976
Score:  0.913
Data Source:  STRINGDB
SPTSSA
Tbio
Family:  Enzyme
Novelty:  0.13352078
Score:  0.908
Data Source:  STRINGDB
ZDHHC9
Tbio
Family:  Enzyme
Novelty:  0.04949094
Score:  0.9
Data Source:  STRINGDB
GOLGA7
Tbio
Novelty:  0.17108842
Score:  0.9
Data Source:  STRINGDB
ORMDL1
Tbio
Novelty:  0.1323746
Score:  0.742
Data Source:  STRINGDB
RNPC3
Tbio
Novelty:  0.07154673
Score:  0.726
Data Source:  STRINGDB
PALMD
Tbio
Novelty:  0.11193793
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risky sexual behaviour measurement
1
1
1
21.5
chronotype measurement
1
1
0
1
12.8
amino acid measurement
1
1
1
2.5
risk-taking behaviour
1
1
1
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risky sexual behaviour measurement
1
21.5
chronotype measurement
0
1
12.8
amino acid measurement
1
2.5
risk-taking behaviour
1
0.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913433
66183
Rat
RGD:2324614
100362555
Dog
serine palmitoyltransferase small subunit B
VGNC:46782
100683817
Horse
serine palmitoyltransferase small subunit B
VGNC:23562
100630248
Cow
serine palmitoyltransferase small subunit B
VGNC:35260
780785
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
serine palmitoyltransferase small subunit B
Horse
serine palmitoyltransferase small subunit B
Cow
serine palmitoyltransferase small subunit B
Publication Statistics
PubMed Score 15.94
PubMed score by year
PubTator Score 13.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title