You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
Q8NFQ8
Torsin-1A-interacting protein 2

Protein Summary
Description
Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. One of the two protein isoforms encoded by this gene is a type II integral membrane protein found in the endoplasmic reticulum (ER). The encoded protein is a cofactor for the ATPase TorsinA, regulating the amount of TorsinA present in the ER compared to that found in the nuclear envelope. Defects in this protein are a cause of early onset primary dystonia, a neuromuscular disease. The other isoform encoded by this gene is an interferon alpha responsive protein whose cellular role has yet to be determined. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367612
  • ENSP00000356584
  • ENSG00000169905
  • ENST00000609928
  • ENSP00000477486

Symbol
  • IFRG15
  • LULL1
  • NET9
  • LULL1
  • IFRG15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
kinase perturbation
0.88
microRNA
0.87
small molecule perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.55   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.55   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999881786
p_ni:  0.000118214
Data Source:  BioPlex
SH3BP4
Tbio
Novelty:  0.13130398
p_int:  0.999400666
p_ni:  0.000561628
p_wrong:  0.000037705
Data Source:  BioPlex
MCU
Tbio
Family:  IC
Novelty:  0.00114914
p_int:  0.996467753
p_ni:  0.003532247
Data Source:  BioPlex
CANT1
Tbio
Family:  Enzyme
Novelty:  0.02640333
p_int:  0.996346215
p_ni:  0.003653785
Data Source:  BioPlex
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
p_int:  0.995056789
p_ni:  0.004943211
Data Source:  BioPlex
MTCH1
Tbio
Novelty:  0.12469914
p_int:  0.991110061
p_ni:  0.008889939
Data Source:  BioPlex
C17orf80
Tbio
Novelty:  0.15267004
p_int:  0.990856327
p_ni:  0.009143673
Data Source:  BioPlex
FPGS
Tchem
Family:  Enzyme
Novelty:  0.0108601
p_int:  0.990396331
p_ni:  0.009405446
p_wrong:  0.000198223
Score:  0.168
Data Source:  BioPlex,STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.987798662
p_ni:  0.012201335
p_wrong:  3e-9
Data Source:  BioPlex
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
p_int:  0.983256433
p_ni:  0.016743567
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
2
4
74
mean corpuscular volume
1
2
4
74
smoking status measurement
2
1
4
57.8
smoking status measurement
2
1
4
57.8
monocyte percentage of leukocytes
1
1
2
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
74
mean corpuscular volume
4
74
smoking status measurement
4
57.8
smoking status measurement
4
57.8
monocyte percentage of leukocytes
2
39.6
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
torsin 1A interacting protein 2
VGNC:10923
456448
Macaque
torsin A interacting protein 2
716654
Mouse
MGI:3582695
240832
Rat
Dog
torsin-1A-interacting protein 2-like
106557472
Species
Name
OMA
EggNOG
Inparanoid
Chimp
torsin 1A interacting protein 2
Macaque
torsin A interacting protein 2
Mouse
Rat
Dog
torsin-1A-interacting protein 2-like
Publication Statistics
PubMed Score 15.55
PubMed score by year
PubTator Score 8.37
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title