Tbio NBEA Neurobeachin

Protein Summary

Description

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q8NFP9
• B7Z2H9
• Q5T320
• Q9HCM8
• Q9NSU1
• Q9NW98
• Q9Y6J1

Gene Name

• NBEA

Ensembl ID

• ENST00000379922
• ENSP00000369254
• ENSG00000172915
• ENST00000400445
• ENSP00000383295
• ENST00000537702
• ENSP00000440233

Symbol

• BCL8B
• KIAA1544
• LYST2
• BCL8B
• LYST2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
trait	0.97
virus perturbation	0.88
microRNA	0.74
cellular component	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.26   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.26   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0