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Tbio
NBEA
Neurobeachin

Protein Summary
Description
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379922
  • ENSP00000369254
  • ENSG00000172915
  • ENST00000400445
  • ENSP00000383295
  • ENST00000537702
  • ENSP00000440233

Symbol
  • BCL8B
  • KIAA1544
  • LYST2
  • BCL8B
  • LYST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
virus perturbation
0.88
microRNA
0.74
cellular component
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.57   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.57   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
ALOXE3
Tbio
Family:  Enzyme
Novelty:  0.02560954
p_int:  0.99999995
p_ni:  6e-9
p_wrong:  4.4e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
FAM124A
Tdark
Novelty:  1.51577847
p_int:  0.999999946
p_ni:  5.2e-8
p_wrong:  2e-9
Data Source:  BioPlex
SHC4
Tbio
Novelty:  0.04623367
p_int:  0.999999745
p_ni:  2.54e-7
p_wrong:  1e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
RD3
Tbio
Novelty:  0.00651981
p_int:  0.999999288
p_ni:  6.48e-7
p_wrong:  6.4e-8
Score:  0.261
Data Source:  BioPlex,STRINGDB
RBM48
Tdark
Novelty:  0.50797247
p_int:  0.999991816
p_ni:  0.000008184
Score:  0.252
Data Source:  BioPlex,STRINGDB
MRPL21
Tdark
Novelty:  0.56552559
p_int:  0.999989903
p_ni:  0.000010097
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.999988165
p_ni:  0.000011835
Score:  0.187
Data Source:  BioPlex,STRINGDB
NAB2
Tbio
Novelty:  0.00860107
p_int:  0.999977521
p_ni:  0.000022163
p_wrong:  3.16e-7
Score:  0.243
Data Source:  BioPlex,STRINGDB
STRADB
Tbio
Family:  Kinase
Novelty:  0.03532206
p_int:  0.99964235
p_ni:  0.000357623
p_wrong:  2.7e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.999569824
p_ni:  0.000430175
Score:  0.669
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
57.6
self reported educational attainment
1
1
1
45.7
refractive error measurement
1
1
1
45.2
1
1
1
31.4
disease progression measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
57.6
self reported educational attainment
1
45.7
refractive error measurement
1
45.2
1
31.4
disease progression measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurobeachin
VGNC:5084
452534
Mouse
MGI:1347075
26422
Dog
neurobeachin
VGNC:43632
477305
Horse
neurobeachin
VGNC:49496
100065416
Cow
neurobeachin
VGNC:31893
525624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurobeachin
Mouse
Dog
neurobeachin
Horse
neurobeachin
Cow
neurobeachin
Publication Statistics
PubMed Score 48.57
PubMed score by year
PubTator Score 17.42
PubTator score by year
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Related Publications
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PMID
Year
Title