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Tbio
NBEA
Neurobeachin

Protein Summary
Description
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379922
  • ENSP00000369254
  • ENSG00000172915
  • ENST00000400445
  • ENSP00000383295
  • ENST00000537702
  • ENSP00000440233

Symbol
  • BCL8B
  • KIAA1544
  • LYST2
  • BCL8B
  • LYST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
virus perturbation
0.88
microRNA
0.74
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (62)
1 – 10 of 62
ALOXE3
Tbio
Family: Enzyme
Novelty: 0.03319677
p_int: 0.99999995
p_ni: 6e-9
p_wrong: 4.4e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
FAM124A
Tdark
Novelty: 3.33333333
p_int: 0.999999946
p_ni: 5.2e-8
p_wrong: 2e-9
Data Source: BioPlex
SHC4
Tbio
Novelty: 0.04557539
p_int: 0.999999745
p_ni: 2.54e-7
p_wrong: 1e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
RD3
Tbio
Novelty: 0.01019584
p_int: 0.999999288
p_ni: 6.48e-7
p_wrong: 6.4e-8
Score: 0.261
Data Source: BioPlex,STRINGDB
RBM48
Tdark
Novelty: 1.00840336
p_int: 0.999991816
p_ni: 0.000008184
Score: 0.252
Data Source: BioPlex,STRINGDB
MRPL21
Tdark
Novelty: 1.72292191
p_int: 0.999989903
p_ni: 0.000010097
p_wrong: 1e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
FOSL2
Tbio
Family: TF
Novelty: 0.006377
p_int: 0.999988165
p_ni: 0.000011835
Score: 0.187
Data Source: BioPlex,STRINGDB
NAB2
Tbio
Novelty: 0.01084363
p_int: 0.999977521
p_ni: 0.000022163
p_wrong: 3.16e-7
Score: 0.243
Data Source: BioPlex,STRINGDB
STRADB
Tbio
Family: Kinase
Novelty: 0.07560756
p_int: 0.99964235
p_ni: 0.000357623
p_wrong: 2.7e-8
Score: 0.207
Data Source: BioPlex,STRINGDB
DLG3
Tbio
Novelty: 0.00904059
p_int: 0.999569824
p_ni: 0.000430175
Score: 0.669
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  32.61

PubMed score by year
PubTator Score  17.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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