Tbio NUDT10 Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Protein Summary

Description

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q8NFP7
• A8K7D7
• D3DX69
• Q86VK1
• Q86VR0
• DIPP-3-alpha

Gene Name

• NUDT10

Ensembl ID

• ENST00000356450
• ENSP00000348831
• ENSG00000122824
• ENST00000376006
• ENSP00000365174

Symbol

• APS2
• DIPP3A
• APS2
• DIPP3a
• DIPP3-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
microRNA	0.66
tissue sample	0.65
cell type or tissue	0.53
chemical	0.47

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Diphosphoinositol Polyphosphate Phosphohydrolase 3-alpha

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Diphosphoinositol Polyphosphate Phosphohydrolase 3-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.61   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.61   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0