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Tbio
MDGA1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Protein Summary
Description
Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434837
  • ENSP00000402584
  • ENSG00000112139
  • ENST00000505425
  • ENSP00000422042

Symbol
  • MAMDC3
  • GPIM
  • MAMDC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.65
tissue
0.62
microRNA
0.58
PubMedID
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.43   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.43   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
Score:  0.96
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.943
Data Source:  STRINGDB
NTNG2
Tbio
Novelty:  0.02827688
Score:  0.935
Data Source:  STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
Score:  0.934
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.915
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.912
Data Source:  STRINGDB
LY6H
Tbio
Novelty:  0.10210816
Score:  0.91
Data Source:  STRINGDB
NTM
Tbio
Novelty:  0.01659865
Score:  0.908
Data Source:  STRINGDB
GPIHBP1
Tbio
Novelty:  0.01241227
Score:  0.908
Data Source:  STRINGDB
CNTN4
Tbio
Novelty:  0.02483465
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
4
64.3
Diuretic use measurement
1
1
1
53.7
insomnia measurement
2
1
0
1
53.3
smoking status measurement
1
1
1
27.3
daytime rest measurement
1
1
1
17.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
64.3
Diuretic use measurement
1
53.7
insomnia measurement
0
1
53.3
smoking status measurement
1
27.3
daytime rest measurement
1
17.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAM domain containing glycosylphosphatidylinositol anchor 1
VGNC:3461
471999
Macaque
MAM domain containing glycosylphosphatidylinositol anchor 1
719423
Mouse
MGI:1922012
74762
Rat
RGD:1307031
309659
Dog
MAM domain containing glycosylphosphatidylinositol anchor 1
VGNC:43101
474893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAM domain containing glycosylphosphatidylinositol anchor 1
Macaque
MAM domain containing glycosylphosphatidylinositol anchor 1
Mouse
Rat
Dog
MAM domain containing glycosylphosphatidylinositol anchor 1
Publication Statistics
PubMed Score 23.43
PubMed score by year
PubTator Score 10.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title