MDGA1
MAM domain-containing glycosylphosphatidylinositol anchor protein 1
Protein Summary
Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016]
- ENST00000434837
- ENSP00000402584
- ENSG00000112139
- ENST00000505425
- ENSP00000422042
- MAMDC3
- GPIM
- MAMDC3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
transcription factor binding site profile | 0.65 | ||
tissue | 0.62 | ||
microRNA | 0.58 | ||
PubMedID | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.43 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 28 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.43 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 28 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (103)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | SynGO | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 3 | 4 | 64.3 | |||||
Diuretic use measurement | 1 | 1 | 1 | 53.7 | |||||
insomnia measurement | 2 | 1 | 0 | 1 | 53.3 | ||||
smoking status measurement | 1 | 1 | 1 | 27.3 | |||||
daytime rest measurement | 1 | 1 | 1 | 17.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 64.3 | |||||
Diuretic use measurement | 1 | 53.7 | |||||
insomnia measurement | 0 | 1 | 53.3 | ||||
smoking status measurement | 1 | 27.3 | |||||
daytime rest measurement | 1 | 17.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MAM domain containing glycosylphosphatidylinositol anchor 1 | VGNC:3461 | 471999 | |||||
Macaque | MAM domain containing glycosylphosphatidylinositol anchor 1 | 719423 | ||||||
Mouse | MGI:1922012 | 74762 | ||||||
Rat | RGD:1307031 | 309659 | ||||||
Dog | MAM domain containing glycosylphosphatidylinositol anchor 1 | VGNC:43101 | 474893 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MAM domain containing glycosylphosphatidylinositol anchor 1 | |||||
Macaque | MAM domain containing glycosylphosphatidylinositol anchor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | MAM domain containing glycosylphosphatidylinositol anchor 1 | |||||
Publication Statistics
PubMed Score 23.43
PubMed score by year
PubTator Score 10.89
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (7)
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0 of 0
PMID | Year | Title |
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