Tbio MDGA1 MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Protein Summary

Description

Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q8NFP4
• A6NHG0
• Q8NBE3

Gene Name

• MDGA1

Ensembl ID

• ENST00000434837
• ENSP00000402584
• ENSG00000112139
• ENST00000505425
• ENSP00000422042

Symbol

• MAMDC3
• GPIM
• MAMDC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor binding site profile	0.65
tissue	0.62
microRNA	0.58
PubMedID	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.98   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.98   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0