Tdark GPR156 Probable G-protein coupled receptor 156

Protein Summary

Description

Orphan receptor. G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NFN8
• B7ZL66
• E9PFZ4
• Q14CM1
• Q86SN6

Gene Name

• GPR156

Ensembl ID

• ENST00000315843
• ENSP00000324553
• ENSG00000175697
• ENST00000461057
• ENSP00000418758
• ENST00000464295
• ENSP00000417261

Symbol

• GABABL
• PGR28
• PGR28
• GABABL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.69
microRNA	0.69
PubMedID	0.51
phenotype	0.5
tissue sample	0.5

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Probable G-protein Coupled Receptor 156

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / Gaba-b Receptor / Probable G-protein Coupled Receptor 156

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0