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Tbio
IL17RD
Interleukin-17 receptor D

Protein Summary
Description
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296318
  • ENSP00000296318
  • ENSG00000144730
  • ENST00000320057
  • ENSP00000322250
  • ENST00000463523
  • ENSP00000417516
  • ENST00000640796
  • ENSP00000492817

Symbol
  • IL17RLM
  • SEF
  • SEF
  • HH18
  • IL-17RD
  • IL17RLM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
transcription factor perturbation
0.68
microRNA
0.65
PubMedID
0.65
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.22   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.22   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.998209469
p_ni:  0.001790531
Score:  0.177
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.990530077
p_ni:  0.009469923
Score:  0.207
Data Source:  BioPlex,STRINGDB
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
p_int:  0.990437438
p_ni:  0.000899342
p_wrong:  0.00866322
Data Source:  BioPlex
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.927698703
p_ni:  0.071474566
p_wrong:  0.000826731
Score:  0.187
Data Source:  BioPlex,STRINGDB
RELT
Tbio
Novelty:  0.07977949
p_int:  0.92229574
p_ni:  0.010762962
p_wrong:  0.066941298
Score:  0.237
Data Source:  BioPlex,STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.921
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.917
Data Source:  STRINGDB
IQGAP1
Tbio
Family:  Enzyme
Novelty:  0.00434481
Score:  0.912
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.906
Data Source:  Reactome,STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.904
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (705)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAP2K and MAPK activation
Reactome
MAPK family signaling cascades
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAP2K and MAPK activation
MAPK family signaling cascades
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 17 receptor D measurement
2
2
2
92.8
cortical surface area measurement
1
1
0
7.9
54.5
body height
1
1
1
41.2
family history of Alzheimer’s disease
1
1
0
5.7
8
Alzheimer disease
1
1
0
5.7
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 17 receptor D measurement
2
92.8
cortical surface area measurement
0
7.9
54.5
body height
1
41.2
family history of Alzheimer’s disease
0
5.7
8
Alzheimer disease
0
5.7
8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor D
VGNC:11417
460467
Macaque
interleukin 17 receptor D
704650
Mouse
MGI:2159727
171463
Rat
RGD:1565237
498576
Dog
interleukin 17 receptor D
VGNC:41949
484719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17 receptor D
Macaque
interleukin 17 receptor D
Mouse
Rat
Dog
interleukin 17 receptor D
Publication Statistics
PubMed Score 54.22
PubMed score by year
PubTator Score 176.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title