Tbio GJC3 Gap junction gamma-3 protein

Protein Summary

Description

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.[provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q8NFK1
• A4D296
• Q86XI9

Gene Name

• GJC3

Ensembl ID

• ENST00000312891
• ENSP00000325775
• ENSG00000176402

Symbol

• GJE1
• CX29
• GJE1
• CX30.2
• CX31.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
histone modification site profile	0.68
protein domain	0.58
tissue sample	0.57
cell line	0.51

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Gap Junction / Gap Junction Gamma-3 Protein

DTO Classes

Protein / Cell-cell Junction / Gap Junction / Gap Junction Gamma-3 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.73   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.73   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0