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Tbio
GJC3
Gap junction gamma-3 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312891
  • ENSP00000325775
  • ENSG00000176402

Symbol
  • GJE1
  • CX29
  • GJE1
  • CX30.2
  • CX31.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
histone modification site profile
0.68
protein domain
0.58
tissue sample
0.57
cell line
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.16   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.16   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (41)
1 – 10 of 41
KCNA2
Tclin
Family: IC
Novelty: 0.00260027
Score: 0.754
Data Source: STRINGDB
AP1S1
Tbio
Novelty: 0.02404649
Score: 0.754
Data Source: STRINGDB
HCN4
Tclin
Family: IC
Novelty: 0.00301943
Score: 0.564
Data Source: STRINGDB
CCDC30
Tdark
Novelty: 0.66666667
Score: 0.552
Data Source: STRINGDB
PANX1
Tbio
Family: IC
Novelty: 0.00209499
Score: 0.537
Data Source: STRINGDB
TBX18
Tbio
Family: TF
Novelty: 0.01534395
Score: 0.521
Data Source: STRINGDB
PANX2
Tbio
Family: IC
Novelty: 0.00929804
Score: 0.512
Data Source: STRINGDB
GJB1
Tbio
Novelty: 0.00115116
Score: 0.482
Data Source: STRINGDB
CDH2
Tbio
Novelty: 0.00055399
Score: 0.48
Data Source: STRINGDB
PANX3
Tbio
Family: IC
Novelty: 0.01038516
Score: 0.476
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.16

PubMed score by year
PubTator Score  17.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer