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Tchem
PROKR2
Prokineticin receptor 2

Protein Summary
Description
Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217270
  • ENSP00000217270
  • ENSG00000101292

Symbol
  • GPR73L1
  • PKR2
  • HH3
  • KAL3
  • PKR2
  • GPRg2
  • GPR73b
  • GPR73L1
  • dJ680N4.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.62
tissue
0.61
cell line
0.58
cell type or tissue
0.57
biological term
0.56


Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.74   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.74   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prokineticin receptor 2
718045
Mouse
MGI:2181363
246313
Rat
RGD:708445
192649
Dog
prokineticin receptor 2
VGNC:45011
485779
Horse
prokineticin receptor 2
VGNC:21873
100052008
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prokineticin receptor 2
Mouse
Rat
Dog
prokineticin receptor 2
Horse
prokineticin receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NFJ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (195)
1 – 10 of 195
PROK2
Tbio
Novelty:  0.00512397
Score:  0.991
Data Source:  Reactome,STRINGDB
PROK1
Tbio
Novelty:  0.01211219
Score:  0.98
Data Source:  Reactome,STRINGDB
TAC3
Tchem
Novelty:  0.001685
Score:  0.969
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.968
Data Source:  STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.962
Data Source:  STRINGDB
EDN3
Tbio
Novelty:  0.00116752
Score:  0.94
Data Source:  STRINGDB
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
Score:  0.927
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.927
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.926
Data Source:  STRINGDB
GNRHR
Tclin
Family:  GPCR
Novelty:  0.00203671
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  76.74

PubMed score by year
PubTator Score  97.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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