Protein Summary
Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
- ENST00000217270
- ENSP00000217270
- ENSG00000101292
- GPR73L1
- PKR2
- HH3
- KAL3
- PKR2
- GPRg2
- GPR73b
- GPR73L1
- dJ680N4.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phenotype | 0.62 | ||
tissue | 0.61 | ||
cell line | 0.58 | ||
cell type or tissue | 0.57 | ||
biological term | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.74 (req: < 5)
Gene RIFs: 48 (req: <= 3)
Antibodies: 225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.74 (req: >= 5)
Gene RIFs: 48 (req: > 3)
Antibodies: 225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (195)
Nearest Tclin Targets
Pathways (9)
Reactome (7)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | prokineticin receptor 2 | 718045 | ||||||
Mouse | MGI:2181363 | 246313 | ||||||
Rat | RGD:708445 | 192649 | ||||||
Dog | prokineticin receptor 2 | VGNC:45011 | 485779 | |||||
Horse | prokineticin receptor 2 | VGNC:21873 | 100052008 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | prokineticin receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | prokineticin receptor 2 | |||||
Horse | prokineticin receptor 2 | |||||
Publication Statistics
PubMed Score 76.74
PubMed score by year
PubTator Score 97.96
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (54)
GeneRif Annotations (48)
Items per page:
0 of 0
PMID | Year | Title |
|---|