Tbio GPRC5A Retinoic acid-induced protein 3

Protein Summary

Description

Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NFJ5
• B3KV45
• O95357

Gene Name

• GPRC5A

Ensembl ID

• ENST00000014914
• ENSP00000014914
• ENSG00000013588

Symbol

• GPCR5A
• RAI3
• RAIG1
• RAI3
• TIG1
• RAIG1
• GPCR5A
• PEIG-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
PubMedID	0.98
transcription factor binding site profile	0.8
transcription factor perturbation	0.8
histone modification site profile	0.79

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Retinoic Acid-induced Protein 3

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / Retinoic Acid-induced Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.03   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 391   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.03   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0