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Tbio
GPRC5A
Retinoic acid-induced protein 3

Protein Summary
Description
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218). This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000014914
  • ENSP00000014914
  • ENSG00000013588

Symbol
  • GPCR5A
  • RAI3
  • RAIG1
  • RAI3
  • TIG1
  • RAIG1
  • GPCR5A
  • PEIG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
PubMedID
0.98
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
histone modification site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.02   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.02   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
GRM2
Tchem
Family:  GPCR
Novelty:  0.00132156
Score:  0.805
Data Source:  STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
Score:  0.713
Data Source:  STRINGDB
SMYD5
Tbio
Family:  Epigenetic
Novelty:  0.11591101
Score:  0.673
Data Source:  STRINGDB
SLC25A3
Tbio
Family:  Transporter
Novelty:  0.00530277
Score:  0.636
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.626
Data Source:  STRINGDB
GTF2F2
Tbio
Novelty:  0.02446629
Score:  0.61
Data Source:  STRINGDB
KRTCAP3
Tdark
Novelty:  0.69717439
Score:  0.605
Data Source:  STRINGDB
TSPEAR
Tbio
Novelty:  0.15908638
Score:  0.564
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.531
Data Source:  STRINGDB
NOLC1
Tbio
Novelty:  0.01922261
Score:  0.51
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
HuR (ELAVL1) binds and stabilizes mRNA (R-HSA-450520)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HuR (ELAVL1) binds and stabilizes mRNA
Reactome
Metabolism of RNA
Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements
Name
Explore in Pharos
Explore in Source
HuR (ELAVL1) binds and stabilizes mRNA
Metabolism of RNA
Regulation of mRNA stability by proteins that bind AU-rich elements
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
2
3
90.9
hematocrit
3
1
3
81.3
red blood cell density measurement
1
1
1
77.9
mean reticulocyte volume
1
1
1
70.8
1
1
0
1.1
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
90.9
hematocrit
3
81.3
red blood cell density measurement
1
77.9
mean reticulocyte volume
1
70.8
0
1.1
62.6
Find similar targets by:
IDG Resources
Mouse
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Details:
  • Allele:  Insertion
Genetic Construct
GPRC5A-Tango
image for GPRC5A-Tango
Details:
  • Vector:  addgene66382
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPRC5A-Tango
Order Genetic Construct from:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor class C group 5 member A [Source:HGNC Symbol;Acc:HGNC:9836]
Macaque
G protein-coupled receptor class C group 5 member A
697555
Mouse
MGI:1891250
232431
Rat
RGD:1310804
312790
Dog
G protein-coupled receptor class C group 5 member A
VGNC:41450
486680
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor class C group 5 member A [Source:HGNC Symbol;Acc:HGNC:9836]
Macaque
G protein-coupled receptor class C group 5 member A
Mouse
Rat
Dog
G protein-coupled receptor class C group 5 member A
Publication Statistics
PubMed Score 69.02
PubMed score by year
PubTator Score 32.25
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title