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Tchem
ENGASE
Cytosolic endo-beta-N-acetylglucosaminidase

Protein Classes
Protein Summary
Description
Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000579016
  • ENSP00000462333
  • ENSG00000167280
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
histone modification site profile
0.82
tissue
0.64
tissue sample
0.61
cellular component
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.75   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.75   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
1
1
0
1.5
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to angiotensin-converting enzyme inhibitor
0
1.5
28.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endo-beta-N-acetylglucosaminidase
VGNC:9421
741918
Macaque
endo-beta-N-acetylglucosaminidase
716600
Mouse
MGI:2443788
217364
Rat
RGD:1310868
303702
Dog
endo-beta-N-acetylglucosaminidase
VGNC:40363
483347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endo-beta-N-acetylglucosaminidase
Macaque
endo-beta-N-acetylglucosaminidase
Mouse
Rat
Dog
endo-beta-N-acetylglucosaminidase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NFI3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Post-translational protein modification
Protein-Protein Interactions (51)
1 – 10 of 51
GNS
Tbio
Family:  Enzyme
Novelty:  0.01528509
p_int:  0.999931915
p_ni:  2.1e-7
p_wrong:  0.000067874
Score:  0.517
Data Source:  BioPlex,STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.904
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.904
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.9
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.9
Data Source:  STRINGDB
NGLY1
Tbio
Family:  Enzyme
Novelty:  0.01017395
Score:  0.874
Data Source:  STRINGDB
GCNT4
Tdark
Family:  Enzyme
Novelty:  0.23258285
Score:  0.786
Data Source:  STRINGDB
MAN2C1
Tbio
Family:  Enzyme
Novelty:  0.01159051
Score:  0.786
Data Source:  STRINGDB
GCNT2
Tbio
Family:  Enzyme
Novelty:  0.03945461
Score:  0.733
Data Source:  STRINGDB
GCNT1
Tbio
Family:  Enzyme
Novelty:  0.01487872
Score:  0.725
Data Source:  STRINGDB
Publication Statistics
PubMed Score  110.75

PubMed score by year
PubTator Score  40.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer