Tbio REPS2 RalBP1-associated Eps domain-containing protein 2

Protein Summary

Description

Involved in growth factor signaling through its influence on the Ral signaling pathway. The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NFH8
• A6PWZ6
• O43428
• Q5JNZ8
• Q8NFI5

Gene Name

• REPS2

Ensembl ID

• ENST00000303843
• ENSP00000306033
• ENSG00000169891
• ENST00000357277
• ENSP00000349824

Symbol

• POB1
• POB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.74
kinase perturbation	0.6
transcription factor	0.59
microRNA	0.58
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Ralbp1-associated Eps Domain-containing Protein 2

Protein / Enzyme Modulator / G-protein Modulator / Ralbp1-associated Eps Domain-containing Protein 2

Protein / Calcium-binding Protein / Ralbp1-associated Eps Domain-containing Protein 2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ralbp1-associated Eps Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0