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Tbio
NUP35
Nucleoporin NUP35

Protein Summary
Description
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295119
  • ENSP00000295119
  • ENSG00000163002
  • ENST00000409798
  • ENSP00000387305

Symbol
  • MP44
  • NUP53
  • MP44
  • NP44
  • MP-44
  • NUP53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
transcription factor binding site profile
0.86
histone modification site profile
0.84
kinase perturbation
0.84
cellular component
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
AAAS
Tbio
Novelty:  0.00830233
p_int:  0.999953001
p_ni:  0.000046999
Score:  0.955
Data Source:  BioPlex,STRINGDB
KCTD9
Tbio
Novelty:  0.22841768
p_int:  0.998787041
p_ni:  0.001212944
p_wrong:  1.5e-8
Score:  0.261
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.996918358
p_ni:  0.003081636
p_wrong:  6e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
ATP23
Tbio
Family:  Enzyme
Novelty:  0.09823059
p_int:  0.99538049
p_ni:  0.004609766
p_wrong:  0.000009745
Score:  0.665
Data Source:  BioPlex,STRINGDB
CCL3L1
Tbio
Novelty:  0.01124082
p_int:  0.993008458
p_ni:  0.006991535
p_wrong:  8e-9
Data Source:  BioPlex
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.975315367
p_ni:  0.024684633
p_wrong:  1e-9
Data Source:  BioPlex
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.952449997
p_ni:  0.047550002
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.933560955
p_ni:  0.066439045
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.92590241
p_ni:  0.07409759
Data Source:  BioPlex
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
p_int:  0.923107725
p_ni:  0.076892218
p_wrong:  5.7e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 35
VGNC:2736
459802
Macaque
nucleoporin 35
706497
Mouse
MGI:1916732
69482
Mouse
MGI:3782538
100043313
Rat
RGD:1303069
295692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 35
Macaque
nucleoporin 35
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 27.74
PubMed score by year
PubTator Score 10.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title