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Tbio
NUP37
Nucleoporin Nup37

Protein Summary
Description
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251074
  • ENSP00000251074
  • ENSG00000075188
  • ENST00000552283
  • ENSP00000448054

Symbol
  • p37
  • MCPH24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
cellular component
0.84
kinase perturbation
0.84
interacting protein
0.79
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.56   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.56   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
76.6
central corneal thickness
1
1
0
2.4
62
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
76.6
central corneal thickness
0
2.4
62
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 37
VGNC:5514
452180
Macaque
nucleoporin 37
697933
Mouse
MGI:1919964
69736
Rat
RGD:1307774
299706
Dog
nucleoporin 37
VGNC:44054
475445
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 37
Macaque
nucleoporin 37
Mouse
Rat
Dog
nucleoporin 37
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NFH4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (82)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (331)
1 – 10 of 331
NUP43
Tbio
Novelty: 0.11571309
p_int: 0.998548823
p_ni: 0.001451177
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP133
Tbio
Novelty: 0.02115225
p_int: 0.969176224
p_ni: 0.030823776
Score: 0.998
Data Source: BioPlex,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.929803582
p_ni: 0.070196418
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP107
Tbio
Novelty: 0.01994155
Score: 0.999
Data Source: STRINGDB
NUP160
Tbio
Novelty: 0.03667026
Score: 0.998
Data Source: STRINGDB
NUP85
Tbio
Novelty: 0.02350514
Score: 0.998
Data Source: STRINGDB
SEH1L
Tbio
Novelty: 0.03666501
Score: 0.995
Data Source: STRINGDB
NUP98
Tbio
Family: Enzyme
Novelty: 0.00401452
Score: 0.995
Data Source: STRINGDB
NUP155
Tbio
Novelty: 0.03884486
Score: 0.993
Data Source: STRINGDB
NUP35
Tbio
Novelty: 0.0355102
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.56

PubMed score by year
PubTator Score  95.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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