Tbio NUP37 Nucleoporin Nup37

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Nucleoporin Nup37

DTO Classes

Protein / Transporter / Nucleoporin Nup37

Protein Summary

Description

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q8NFH4
• Q9H644
• p37

Gene Name

• NUP37

Ensembl ID

• ENST00000251074
• ENSP00000251074
• ENSG00000075188
• ENST00000552283
• ENSP00000448054

Symbol

• p37
• MCPH24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	1
cellular component	0.84
kinase perturbation	0.84
interacting protein	0.79
trait	0.75

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.56   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.56   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		76.6
central corneal thickness	EFO_0005213	1	1	0	2.4	62

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		76.6
central corneal thickness	EFO_0005213	0	2.4	62

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 37	VGNC:5514	452180
Macaque	nucleoporin 37		697933
Mouse	nucleoporin 37	MGI:1919964	69736
Rat	nucleoporin 37	RGD:1307774	299706
Dog	nucleoporin 37	VGNC:44054	475445

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 37
Macaque	nucleoporin 37
Mouse	nucleoporin 37
Rat	nucleoporin 37
Dog	nucleoporin 37

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NFH4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (82)

Reactome (81)

KEGG (1)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620

Gene Ontology Terms (11)

Components (6)

Processes (5)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
nuclear pore outer ring	Inferred from Direct Assay (IDA)	UniProtKB
nucleoplasm	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
cytosol	Traceable Author Statement (TAS)	Reactome
nuclear envelope	Traceable Author Statement (TAS)	Reactome
condensed chromosome kinetochore	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (331)

Explore Interacting Targets

1 – 10 of 331

• See Interactions on String-DB

NUP43

Tbio

Novelty: 0.11571309

p_int: 0.998548823

p_ni: 0.001451177

Score: 0.999

Data Source: BioPlex,STRINGDB

NUP133

Tbio

Novelty: 0.02115225

p_int: 0.969176224

p_ni: 0.030823776

Score: 0.998

Data Source: BioPlex,STRINGDB

SEC13

Tbio

Novelty: 0.00709413

p_int: 0.929803582

p_ni: 0.070196418

Score: 0.999

Data Source: BioPlex,STRINGDB

NUP107

Tbio

Novelty: 0.01994155

Score: 0.999

Data Source: STRINGDB

NUP160

Tbio

Novelty: 0.03667026

Score: 0.998

Data Source: STRINGDB

NUP85

Tbio

Novelty: 0.02350514

Score: 0.998

Data Source: STRINGDB

SEH1L

Tbio

Novelty: 0.03666501

Score: 0.995

Data Source: STRINGDB

NUP98

Tbio

Family: Enzyme

Novelty: 0.00401452

Score: 0.995

Data Source: STRINGDB

NUP155

Tbio

Novelty: 0.03884486

Score: 0.993

Data Source: STRINGDB

NUP35

Tbio

Novelty: 0.0355102

Score: 0.986

Data Source: STRINGDB

Publication Statistics

PubMed Score  7.56

PubMed score by year

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PubTator Score  95.88

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Cell cycle
Cell division
Centromere
Chromosome
Chromosome partition
Complete proteome
Kinetochore
Mitosis
mRNA transport

GWAS Trait Find Similar Targets

body height
central corneal thickness

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype