Protein Summary
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]
- ENST00000251074
- ENSP00000251074
- ENSG00000075188
- ENST00000552283
- ENSP00000448054
- p37
- MCPH24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 1 | ||
cellular component | 0.84 | ||
kinase perturbation | 0.84 | ||
interacting protein | 0.79 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.64 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.64 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (331)
NUP43
Novelty: 0.11571309
p_int: 0.998548823
p_ni: 0.001451177
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP133
Novelty: 0.02115225
p_int: 0.969176224
p_ni: 0.030823776
Score: 0.998
Data Source: BioPlex,STRINGDB
SEC13
Novelty: 0.00709413
p_int: 0.929803582
p_ni: 0.070196418
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (82)
Reactome (81)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 3 | 3 | 3 | 97.3 | |||||
IGF-1 measurement | 1 | 2 | 2 | 89.4 | |||||
central corneal thickness | 1 | 1 | 0 | 2.4 | 64.4 | ||||
risk-taking behaviour | 2 | 2 | 2 | 62.8 | |||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 60.1 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 3 | 97.3 | |||||
IGF-1 measurement | 2 | 89.4 | |||||
central corneal thickness | 0 | 2.4 | 64.4 | ||||
risk-taking behaviour | 2 | 62.8 | |||||
BMI-adjusted hip circumference | 3 | 60.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nucleoporin 37 | VGNC:5514 | 452180 | |||||
Macaque | nucleoporin 37 | 697933 | ||||||
Mouse | MGI:1919964 | 69736 | ||||||
Rat | RGD:1307774 | 299706 | ||||||
Dog | nucleoporin 37 | VGNC:44054 | 475445 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nucleoporin 37 | |||||
Macaque | nucleoporin 37 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nucleoporin 37 | |||||
Publication Statistics
PubMed Score 9.64
PubMed score by year
PubTator Score 95.88
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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