Tbio NUP37 Nucleoporin Nup37

Protein Summary

Description

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q8NFH4
• Q9H644
• p37

Gene Name

• NUP37

Ensembl ID

• ENST00000251074
• ENSP00000251074
• ENSG00000075188
• ENST00000552283
• ENSP00000448054

Symbol

• p37
• MCPH24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	1
cellular component	0.84
kinase perturbation	0.84
interacting protein	0.79
trait	0.75

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.64   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.64   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (331)

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1 – 10 of 331

• See Interactions on String-DB

NUP43

Tbio

Novelty:  0.11571309

p_int:  0.998548823

p_ni:  0.001451177

Score:  0.999

Data Source:  BioPlex,STRINGDB

NUP133

Tbio

Novelty:  0.02115225

p_int:  0.969176224

p_ni:  0.030823776

Score:  0.998

Data Source:  BioPlex,STRINGDB

SEC13

Tbio

Novelty:  0.00709413

p_int:  0.929803582

p_ni:  0.070196418

Score:  0.999

Data Source:  BioPlex,STRINGDB

NUP107

Tbio

Novelty:  0.01994155

Score:  0.999

Data Source:  STRINGDB

NUP160

Tbio

Novelty:  0.03667026

Score:  0.998

Data Source:  STRINGDB

NUP85

Tbio

Novelty:  0.02350514

Score:  0.998

Data Source:  STRINGDB

SEH1L

Tbio

Novelty:  0.03666501

Score:  0.995

Data Source:  STRINGDB

NUP98

Tbio

Family:  Enzyme

Novelty:  0.00401452

Score:  0.995

Data Source:  STRINGDB

NUP155

Tbio

Novelty:  0.03884486

Score:  0.993

Data Source:  STRINGDB

NUP35

Tbio

Novelty:  0.0355102

Score:  0.986

Data Source:  STRINGDB

Pathways (82)

Reactome (81)

KEGG (1)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620

Gene Ontology Terms (11)

Components (6)

Processes (5)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
nuclear pore outer ring	Inferred from Direct Assay (IDA)	UniProtKB
nucleoplasm	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
cytosol	Traceable Author Statement (TAS)	Reactome
nuclear envelope	Traceable Author Statement (TAS)	Reactome
condensed chromosome kinetochore	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

GWAS Traits (10)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	3	3	3		97.3
IGF-1 measurement	EFO_0004627	1	2	2		89.4
central corneal thickness	EFO_0005213	1	1	0	2.4	64.4
risk-taking behaviour	EFO_0008579	2	2	2		62.8
BMI-adjusted hip circumference	EFO_0008039	2	2	3		60.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	3		97.3
IGF-1 measurement	EFO_0004627	2		89.4
central corneal thickness	EFO_0005213	0	2.4	64.4
risk-taking behaviour	EFO_0008579	2		62.8
BMI-adjusted hip circumference	EFO_0008039	3		60.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell cycle
Cell division
Centromere
Chromosome
Chromosome partition
Complete proteome
Kinetochore
Mitosis
mRNA transport

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
central corneal thickness
IGF-1 measurement
restless legs syndrome
risk-taking behaviour
risky sexual behaviour measurement
sex hormone-binding globulin measurement
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 37	VGNC:5514	452180
Macaque	nucleoporin 37		697933
Mouse	nucleoporin 37	MGI:1919964	69736
Rat	nucleoporin 37	RGD:1307774	299706
Dog	nucleoporin 37	VGNC:44054	475445

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 37
Macaque	nucleoporin 37
Mouse	nucleoporin 37
Rat	nucleoporin 37
Dog	nucleoporin 37

Publication Statistics

PubMed Score 9.64

PubMed score by year

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PubTator Score 95.88

PubTator score by year

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