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Tbio
NUP43
Nucleoporin Nup43

Protein Summary
Description
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340413
  • ENSP00000342262
  • ENSG00000120253
  • ENST00000367404
  • ENSP00000356374

Symbol
  • p42
  • bA350J20.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
transcription factor perturbation
0.74
cellular component
0.7
biological process
0.67
transcription factor binding site profile
0.65


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 43
VGNC:3601
472151
Mouse
MGI:1917162
69912
Rat
RGD:1596513
683983
Dog
nucleoporin 43
VGNC:44055
484031
Horse
nucleoporin 43
VGNC:20970
100064615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 43
Mouse
Rat
Dog
nucleoporin 43
Horse
nucleoporin 43
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NFH3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (82)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (264)
1 – 10 of 264
TPRKB
Tbio
Novelty: 0.1035085
p_int: 0.999917847
p_ni: 0.000082153
Score: 0.757
Data Source: BioPlex,STRINGDB
NUP98
Tbio
Family: Enzyme
Novelty: 0.00401452
p_int: 0.999913269
p_ni: 0.000086731
Score: 0.999
Data Source: BioPlex,STRINGDB
KLC4
Tdark
Novelty: 0.32552746
p_int: 0.9998631
p_ni: 0.000136899
Score: 0.158
Data Source: BioPlex,STRINGDB
NUP85
Tbio
Novelty: 0.02350514
p_int: 0.999794211
p_ni: 0.000205789
Score: 0.999
Data Source: BioPlex,STRINGDB
OSGEP
Tbio
Family: Enzyme
Novelty: 0.0106198
p_int: 0.999615467
p_ni: 0.000384533
Score: 0.756
Data Source: BioPlex,STRINGDB
NUP107
Tbio
Novelty: 0.01994155
p_int: 0.999534073
p_ni: 0.000465927
Score: 0.999
Data Source: BioPlex,STRINGDB
TP53RK
Tbio
Family: Kinase
Novelty: 0.04302252
p_int: 0.998737133
p_ni: 0.001262867
Score: 0.763
Data Source: BioPlex,STRINGDB
NUP160
Tbio
Novelty: 0.03667026
p_int: 0.998616281
p_ni: 0.001383359
p_wrong: 3.6e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP37
Tbio
Novelty: 0.1270421
p_int: 0.998548823
p_ni: 0.001451177
Score: 0.999
Data Source: BioPlex,STRINGDB
XPA
Tbio
Novelty: 0.00137698
p_int: 0.998303008
p_ni: 0.001696992
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.61

PubMed score by year
PubTator Score  2.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer