Protein Summary
May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000285071
- ENSP00000285071
- ENSG00000154803
- ENST00000389169
- ENSP00000373821
- BHD
- BHD
- FLCL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
disease perturbation | 0.96 | ||
histone modification site profile | 0.92 | ||
interacting protein | 0.81 | ||
transcription factor binding site profile | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 516.07 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 285 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 516.07 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 285 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
WDFY3
Novelty: 0.01670166
p_int: 0.999998606
p_ni: 0.000001394
Score: 0.185
Data Source: BioPlex,STRINGDB
CTAG2
Novelty: 0.02983879
p_int: 0.999997128
p_ni: 0.000002871
p_wrong: 1e-9
Data Source: BioPlex
FAM120B
Novelty: 0.07982799
p_int: 0.999993764
p_ni: 0.000006236
Score: 0.239
Data Source: BioPlex,STRINGDB
DPEP1
Family: Enzyme
Novelty: 0.00384946
p_int: 0.999988829
p_ni: 0.000011171
Data Source: BioPlex
LDLRAD4
Novelty: 0.04881486
p_int: 0.99998583
p_ni: 0.000010144
p_wrong: 0.000004026
Score: 0.202
Data Source: BioPlex,STRINGDB
AGAP3
Family: Enzyme
Novelty: 0.15649084
p_int: 0.999979025
p_ni: 0.000020975
Score: 0.188
Data Source: BioPlex,STRINGDB
POLR3K
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999963344
p_ni: 0.000036652
p_wrong: 4e-9
Data Source: BioPlex
SEMA4C
Novelty: 0.01237067
p_int: 0.999684493
p_ni: 0.000306398
p_wrong: 0.000009109
Data Source: BioPlex
AGAP1
Family: Enzyme
Novelty: 0.06776705
p_int: 0.998869253
p_ni: 0.000903203
p_wrong: 0.000227544
Score: 0.188
Data Source: BioPlex,STRINGDB
CTAG1A
Novelty: 0.00345306
p_int: 0.99859578
p_ni: 0.000995135
p_wrong: 0.000409086
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
KEGG (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | mTOR signaling pathway | ||||
KEGG | Renal cell carcinoma | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
mTOR signaling pathway | ||||
Renal cell carcinoma | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (2)
Components (6)
Processes (30)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 74 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 72.2 | |||||
hemoglobin measurement | 1 | 1 | 1 | 49.5 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 31.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 24.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 74 | |||||
mean reticulocyte volume | 1 | 72.2 | |||||
hemoglobin measurement | 1 | 49.5 | |||||
neutrophil percentage of leukocytes | 1 | 31.4 | |||||
mean corpuscular volume | 1 | 24.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | folliculin | 698082 | ||||||
Mouse | MGI:2442184 | 216805 | ||||||
Rat | RGD:735088 | 303185 | ||||||
Dog | folliculin | 479529 | ||||||
Horse | folliculin | 100052790 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | folliculin | |||||
Mouse | ||||||
Rat | ||||||
Dog | folliculin | |||||
Horse | folliculin | |||||
Publication Statistics
PubMed Score 516.07
PubMed score by year
PubTator Score 239.31
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (77)
Items per page:
0 of 0
PMID | Year | Title |
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