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Tbio
SLC24A4
Sodium/potassium/calcium exchanger 4

Protein Classes
Protein Summary
Description
Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393265
  • ENSP00000376948
  • ENSG00000140090
  • ENST00000531433
  • ENSP00000433302
  • ENST00000532405
  • ENSP00000431840

Symbol
  • NCKX4
  • AI2A5
  • NCKX4
  • SHEP6
  • SLC24A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
microRNA
0.78
cell type or tissue
0.73
transcription factor
0.68
disease
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.04   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.04   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) (R-HSA-5619055)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Protein-Protein Interactions (98)
1 – 10 of 98
TPCN2
Tchem
Family: IC
Novelty: 0.01836974
Score: 0.814
Data Source: STRINGDB
WDR72
Tbio
Novelty: 0.10776436
Score: 0.799
Data Source: STRINGDB
NME8
Tbio
Novelty: 0.08201989
Score: 0.737
Data Source: STRINGDB
LAMB3
Tbio
Novelty: 0.00846457
Score: 0.735
Data Source: STRINGDB
ZCWPW1
Tdark
Family: Epigenetic
Novelty: 0.20950083
Score: 0.734
Data Source: STRINGDB
DLX3
Tbio
Family: TF
Novelty: 0.00977516
Score: 0.72
Data Source: STRINGDB
RIN3
Tbio
Novelty: 0.04345325
Score: 0.718
Data Source: STRINGDB
OCA2
Tbio
Novelty: 0.00300697
Score: 0.716
Data Source: STRINGDB
CASS4
Tbio
Novelty: 0.01164407
Score: 0.705
Data Source: STRINGDB
SLC45A2
Tbio
Family: Transporter
Novelty: 0.00274342
Score: 0.701
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.04

PubMed score by year
PubTator Score  18.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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