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Tbio
ARID1B
AT-rich interactive domain-containing protein 1B

Protein Summary
Description
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350026
  • ENSP00000055163
  • ENSG00000049618
  • ENST00000636930
  • ENSP00000490491
  • ENST00000637810
  • ENSP00000489636
  • ENST00000647938
  • ENSP00000498155

Symbol
  • BAF250B
  • DAN15
  • KIAA1235
  • OSA2
  • CSS1
  • OSA2
  • 6A3-5
  • DAN15
  • MRD12
  • P250R
  • BRIGHT
  • BAF250B
  • ELD/OSA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
transcription factor binding site profile
0.89
microRNA
0.75
cell line
0.72
interacting protein
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.3   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.3   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
82
cognitive function measurement
3
2
3
76.4
self reported educational attainment
2
2
2
74
intelligence
1
1
0
6.1
73.5
heel bone mineral density
2
1
2
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
82
cognitive function measurement
3
76.4
self reported educational attainment
2
74
intelligence
0
6.1
73.5
heel bone mineral density
2
72.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 1B
VGNC:2667
463090
Macaque
AT-rich interaction domain 1B
708362
Mouse
MGI:1926129
239985
Rat
RGD:708504
282546
Dog
AT-rich interaction domain 1B
VGNC:53524
484047
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AT-rich interaction domain 1B
Macaque
AT-rich interaction domain 1B
Mouse
Rat
Dog
AT-rich interaction domain 1B
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
RMTs methylate histone arginines
Protein-Protein Interactions (107)
1 – 10 of 107
DPF3
Tbio
Family: Epigenetic
Novelty: 0.069151
p_int: 0.999999807
p_ni: 1.93e-7
Score: 0.992
Data Source: BioPlex,STRINGDB
DPF2
Tbio
Family: Epigenetic
Novelty: 0.0403366
p_int: 0.999999617
p_ni: 3.8e-7
p_wrong: 3e-9
Score: 0.963
Data Source: BioPlex,STRINGDB
SS18
Tbio
Novelty: 0.00915548
p_int: 0.999999372
p_ni: 6.21e-7
p_wrong: 7e-9
Score: 0.949
Data Source: BioPlex,STRINGDB
SMARCB1
Tbio
Novelty: 0.00116387
p_int: 0.999999103
p_ni: 8.97e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.99999872
p_ni: 0.000001279
p_wrong: 1e-9
Score: 0.925
Data Source: BioPlex,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.999998691
p_ni: 0.000001308
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.999998373
p_ni: 0.000001626
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.999996421
p_ni: 0.000003575
p_wrong: 4e-9
Score: 0.946
Data Source: BioPlex,STRINGDB
SMARCE1
Tbio
Family: TF
Novelty: 0.01748089
p_int: 0.999915511
p_ni: 0.000084489
Score: 0.997
Data Source: BioPlex,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.998641368
p_ni: 0.001358632
Data Source: BioPlex
Publication Statistics
PubMed Score  134.30

PubMed score by year
PubTator Score  80.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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