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Tbio
ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

Protein Summary
Description
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303941
  • ENSP00000306678
  • ENSG00000170209

Symbol
  • PKK2
  • SGK288
  • PKK2
  • sgK288
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
protein domain
0.85
biological term
0.79
tissue sample
0.72
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.01   (req: < 5)
Gene RIFs: 114   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.01   (req: >= 5)
Gene RIFs: 114   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
2
1
2
83.1
lifestyle measurement
1
1
1
60.9
alcohol consumption measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
2
83.1
lifestyle measurement
1
60.9
alcohol consumption measurement
1
16.8
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (59)
1 – 10 of 59
TTC12
Tbio
Novelty: 0.08770001
Score: 0.926
Data Source: STRINGDB
DRD2
Tclin
Family: GPCR
Novelty: 0.00033797
Score: 0.903
Data Source: STRINGDB
PDZD7
Tbio
Novelty: 0.09467006
Score: 0.803
Data Source: STRINGDB
COMT
Tclin
Family: Enzyme
Novelty: 0.00025107
Score: 0.738
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00099622
Score: 0.738
Data Source: STRINGDB
SLC6A3
Tclin
Family: Transporter
Novelty: 0.00017601
Score: 0.677
Data Source: STRINGDB
NCAM1
Tbio
Novelty: 0.00020994
Score: 0.671
Data Source: STRINGDB
CHRNA5
Tbio
Family: IC
Novelty: 0.00425291
Score: 0.668
Data Source: STRINGDB
SLC6A4
Tclin
Family: Transporter
Novelty: 0.00017603
Score: 0.647
Data Source: STRINGDB
GABRA2
Tclin
Family: IC
Novelty: 0.00663529
Score: 0.643
Data Source: STRINGDB
Publication Statistics
PubMed Score  155.01

PubMed score by year
PubTator Score  120.59

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer