Tdark BOD1L1 Biorientation of chromosomes in cell division protein 1-like 1

Protein Summary

Description

Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).

Uniprot Accession IDs

• Q8NFC6
• Q6P0M8
• Q96AL1
• Q9H6G0
• Q9NTD6
• Q9P2L9

Gene Name

• BOD1L1

Ensembl ID

• ENST00000040738
• ENSP00000040738
• ENSG00000038219

Symbol

• BOD1L
• FAM44A
• KIAA1327
• BOD1L
• FAM44A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
cell type or tissue	0.87
transcription factor binding site profile	0.86
virus perturbation	0.76
drug perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0