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Tbio
NOXO1
NADPH oxidase organizer 1

Protein Summary
Description
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354249
  • ENSP00000346195
  • ENSG00000196408
  • ENST00000356120
  • ENSP00000348435
  • ENST00000397280
  • ENSP00000380450
  • ENST00000566005
  • ENSP00000456800

Symbol
  • P41NOX
  • SH3PXD5
  • SNX28
  • P41NOX
  • P41NOXA
  • P41NOXB
  • P41NOXC
  • SH3PXD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.74
molecular function
0.49
cell line
0.48
metabolite
0.45
biological term
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.66   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.66   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
92
glomerular filtration rate
2
2
2
78.7
2
3
0
1.1
77.8
hemoglobin measurement
2
1
2
75.6
red blood cell density measurement
1
1
1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
92
glomerular filtration rate
2
78.7
0
1.1
77.8
hemoglobin measurement
2
75.6
red blood cell density measurement
1
71.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADPH oxidase organizer 1
VGNC:13751
468090
Macaque
NADPH oxidase organizer 1
694059
Mouse
MGI:1919143
71893
Dog
NADPH oxidase organizer 1
VGNC:43907
490063
Horse
NADPH oxidase organizer 1
VGNC:51178
100068060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADPH oxidase organizer 1
Macaque
NADPH oxidase organizer 1
Mouse
Dog
NADPH oxidase organizer 1
Horse
NADPH oxidase organizer 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NFA2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (129)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate NADPH Oxidases
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate NADPH Oxidases
Signal Transduction
Signaling by Rho GTPases
Protein-Protein Interactions (33)
1 – 10 of 33
MAP1S
Tbio
Novelty:  0.02643414
p_int:  0.999994521
p_ni:  0.000005479
Data Source:  BioPlex
MAP1B
Tchem
Novelty:  0.00215274
p_int:  0.998152311
p_ni:  0.001847689
Data Source:  BioPlex
ARHGAP8
Tbio
Family:  Enzyme
Novelty:  0.22016818
p_int:  0.956218287
p_ni:  0.043781712
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.916802652
p_ni:  0.083197349
Data Source:  BioPlex
HSPA2
Tchem
Novelty:  0.01696667
p_int:  0.882140655
p_ni:  0.117859346
Data Source:  BioPlex
HSPA6
Tbio
Novelty:  0.00654285
p_int:  0.858571443
p_ni:  0.141428557
Data Source:  BioPlex
NOXA1
Tbio
Family:  Enzyme
Novelty:  0.03052419
Score:  0.995
Data Source:  Reactome,STRINGDB
CYBA
Tbio
Novelty:  0.00177762
Score:  0.99
Data Source:  Reactome,STRINGDB
NOX1
Tchem
Family:  Enzyme
Novelty:  0.0016839
Score:  0.986
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.95
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  31.66

PubMed score by year
PubTator Score  23.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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