ZNF397
Zinc finger protein 397
Protein Summary
Isoform 3 acts as a DNA-dependent transcriptional repressor. This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
- ENST00000261333
- ENSP00000261333
- ENSG00000186812
- ENST00000330501
- ENSP00000331577
- ENST00000585800
- ENSP00000466760
- ENST00000591206
- ENSP00000466317
- ZNF47
- ZSCAN15
- ZNF47
- ZSCAN15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.85 | ||
kinase perturbation | 0.76 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.71 | ||
microRNA | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.07 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.07 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0