Protein Summary
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermati ...more
- ENST00000367253
- ENSP00000356222
- ENSG00000131018
- ENST00000367255
- ENSP00000356224
- ENST00000413186
- ENSP00000414510
- C6orf98
- KIAA0796
- KIAA1262
- KIAA1756
- MYNE1
- 8B
- CPG2
- ARCA1
- EDMD4
- KASH1
- MYNE1
- Nesp1
- SCAR8
- C6orf98
- dJ45H2.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 1 | ||
interacting protein | 0.99 | ||
cellular component | 0.97 | ||
transcription factor perturbation | 0.91 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 313.59 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 313.59 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (165)
IFT57
Novelty: 0.03373199
p_int: 0.999999769
p_ni: 2.31e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
TNFSF18
Novelty: 0.01423949
p_int: 0.996173152
p_ni: 0.003270801
p_wrong: 0.000556046
Data Source: BioPlex
MMP19
Family: Enzyme
Novelty: 0.01407961
p_int: 0.93162791
p_ni: 0.005691403
p_wrong: 0.062680687
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (4)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Meiosis | ||||
Reactome | Meiotic synapsis | ||||
Reactome | Reproduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Meiosis | ||||
Meiotic synapsis | ||||
Reproduction | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (7)
Components (14)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 3 | 0 | 1.2 | 92.9 | |||||
heel bone mineral density | 3 | 6 | 8 | 92.1 | |||||
body height | 2 | 2 | 2 | 87.6 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 74.5 | |||||
myeloid white cell count | 1 | 1 | 1 | 72.3 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 92.9 | |||||
heel bone mineral density | 8 | 92.1 | |||||
body height | 2 | 87.6 | |||||
serum gamma-glutamyl transferase measurement | 1 | 74.5 | |||||
myeloid white cell count | 1 | 72.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | spectrin repeat containing nuclear envelope protein 1 | 711782 | ||||||
Dog | spectrin repeat containing nuclear envelope protein 1 | VGNC:47027 | 484037 | |||||
Horse | spectrin repeat containing nuclear envelope protein 1 | VGNC:23801 | 100062842 | |||||
Opossum | spectrin repeat containing nuclear envelope protein 1 | 100032170 | ||||||
Platypus | spectrin repeat containing nuclear envelope protein 1 | 100073483 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | spectrin repeat containing nuclear envelope protein 1 | |||||
Dog | spectrin repeat containing nuclear envelope protein 1 | |||||
Horse | spectrin repeat containing nuclear envelope protein 1 | |||||
Opossum | spectrin repeat containing nuclear envelope protein 1 | |||||
Platypus | spectrin repeat containing nuclear envelope protein 1 | |||||
Publication Statistics
PubMed Score 313.59
PubMed score by year
PubTator Score 102.08
PubTator score by year
Related Publications
Text Mined References (74)
GeneRif Annotations (49)
Items per page:
0 of 0
PMID | Year | Title |
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