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Tbio
SYNE1
Nesprin-1

Protein Summary
Description
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly. Required for centrosome migration to the apical cell surface during early ciliogenesis. May be involved in nuclear remodeling during sperm head formation in spermatogenenis; a probable SUN3:SYNE1/KASH1 LINC complex may tether spermati ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
interacting protein
0.99
cellular component
0.97
transcription factor perturbation
0.91
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.1   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.1   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
6
8
95.2
2
3
0
1.2
93.3
1
1
0
1.1
40
1
1
0
1.1
34.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
95.2
0
1.2
93.3
0
1.1
40
0
1.1
34.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spectrin repeat containing nuclear envelope protein 1
711782
Dog
spectrin repeat containing nuclear envelope protein 1
VGNC:47027
484037
Horse
spectrin repeat containing nuclear envelope protein 1
VGNC:23801
100062842
Opossum
spectrin repeat containing nuclear envelope protein 1
100032170
Platypus
spectrin repeat containing nuclear envelope protein 1
100073483
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spectrin repeat containing nuclear envelope protein 1
Dog
spectrin repeat containing nuclear envelope protein 1
Horse
spectrin repeat containing nuclear envelope protein 1
Opossum
spectrin repeat containing nuclear envelope protein 1
Platypus
spectrin repeat containing nuclear envelope protein 1
Protein Structure (1 Structure, 38 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic synapsis
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic synapsis
Reproduction
Gene Ontology Terms (27)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (165)
1 – 10 of 165
IFT57
Tbio
Novelty: 0.03373199
p_int: 0.999999769
p_ni: 2.31e-7
Score: 0.213
Data Source: BioPlex,STRINGDB
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.996173152
p_ni: 0.003270801
p_wrong: 0.000556046
Data Source: BioPlex
MMP19
Tbio
Family: Enzyme
Novelty: 0.01407961
p_int: 0.93162791
p_ni: 0.005691403
p_wrong: 0.062680687
Data Source: BioPlex
SUN2
Tbio
Novelty: 0.01387591
Score: 0.998
Data Source: STRINGDB
SUN1
Tbio
Novelty: 0.00931817
Score: 0.994
Data Source: STRINGDB
LMNB1
Tbio
Novelty: 0.00127348
Score: 0.983
Data Source: STRINGDB
SYNE3
Tbio
Novelty: 0.06515065
Score: 0.929
Data Source: STRINGDB
SYNE2
Tbio
Novelty: 0.01368736
Score: 0.928
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.927
Data Source: STRINGDB
SMC3
Tbio
Novelty: 0.00474377
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  304.10

PubMed score by year
PubTator Score  102.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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