Tbio LPCAT1 Lysophosphatidylcholine acyltransferase 1

Protein Summary

Description

Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:21498505). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (PubMed:25491198). This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q8NF37
• Q1HAQ1
• Q7Z4G6
• Q8N3U7
• Q8WUL8
• Q9GZW6
• LPC acyltransferase 1

Gene Name

• LPCAT1

Ensembl ID

• ENST00000283415
• ENSP00000283415
• ENSG00000153395
• ENST00000475622
• ENSP00000423472

Symbol

• AYTL2
• PFAAP3
• AYTL2
• lpcat
• AGPAT9
• PFAAP3
• AGPAT10
• LPCAT-1
• lysoPAFAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor perturbation	0.88
metabolite	0.81
interacting protein	0.8
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Lysophosphatidylcholine Acyltransferase 1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Lysophosphatidylcholine Acyltransferase 1

Protein / Calcium-binding Protein / Annexin / Lysophosphatidylcholine Acyltransferase 1

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Lysophosphatidylcholine Acyltransferase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.05   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.05   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0