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Tbio
FBXO22
F-box only protein 22

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308275
  • ENSP00000307833
  • ENSG00000167196
  • ENST00000453211
  • ENSP00000396442
  • ENST00000569022
  • ENSP00000457531

Symbol
  • FBX22
  • FBX22
  • FISTC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.9
transcription factor binding site profile
0.83
transcription factor perturbation
0.8
small molecule perturbation
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 22
VGNC:3544
453771
Mouse
MGI:1926014
71999
Rat
RGD:1306664
300724
Dog
F-box protein 22
VGNC:40767
487672
Cow
F-box protein 22
VGNC:28899
536605
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 22
Mouse
Rat
Dog
F-box protein 22
Cow
F-box protein 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NEZ5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (331)
1 – 10 of 331
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999897014
p_ni: 0.000102986
Score: 0.969
Data Source: BioPlex,STRINGDB
BACH1
Tbio
Family: TF
Novelty: 0.04011328
p_int: 0.997396719
p_ni: 0.002603281
Score: 0.29
Data Source: BioPlex,STRINGDB
TTC9C
Tdark
Novelty: 0.85949913
p_int: 0.992467134
p_ni: 0.007532866
Data Source: BioPlex
FBXO21
Tbio
Novelty: 0.2186203
Score: 0.961
Data Source: STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.958
Data Source: STRINGDB
FBXL4
Tbio
Novelty: 0.04286856
Score: 0.943
Data Source: STRINGDB
FBXL18
Tdark
Novelty: 0.33137957
Score: 0.943
Data Source: STRINGDB
UBE2Q2
Tbio
Novelty: 0.12491522
Score: 0.942
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.933
Data Source: STRINGDB
COPS5
Tbio
Novelty: 0.00406225
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.81

PubMed score by year
PubTator Score  4.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer