Tbio PPHLN1 Periphilin-1

Protein Summary

Description

Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (Probable). The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NEY8
• E9PAX8
• Q86YT2
• Q8IXN3
• Q8TB09
• Q96NB9
• Q9NXL4
• Q9P0P6
• Q9P0R9

Gene Name

• PPHLN1

Ensembl ID

• ENST00000358314
• ENSP00000351066
• ENSG00000134283
• ENST00000395568
• ENSP00000378935
• ENST00000395580
• ENSP00000378947
• ENST00000432191
• ENSP00000393965
• ENST00000449194
• ENSP00000390681
• ENST00000552761
• ENSP00000449331
• ENST00000610488
• ENSP00000479913
• ENST00000613154
• ENSP00000478872
• ENST00000619544
• ENSP00000477681

Symbol

• CR
• HSPC206
• HSPC232

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.82
kinase perturbation	0.81
virus perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0