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Tbio
PPHLN1
Periphilin-1

Protein Summary
Description
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (Probable). The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358314
  • ENSP00000351066
  • ENSG00000134283
  • ENST00000395568
  • ENSP00000378935
  • ENST00000395580
  • ENSP00000378947
  • ENST00000432191
  • ENSP00000393965
  • ENST00000449194
  • ENSP00000390681
  • ENST00000552761
  • ENSP00000449331
  • ENST00000610488
  • ENSP00000479913
  • ENST00000613154
  • ENSP00000478872
  • ENST00000619544
  • ENSP00000477681

Symbol
  • CR
  • HSPC206
  • HSPC232
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.82
kinase perturbation
0.81
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.02   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
15.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
15.3
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (43)
1 – 10 of 43
ERH
Tbio
Novelty: 0.00711649
p_int: 0.999988141
p_ni: 0.000011859
Data Source: BioPlex
MFAP4
Tbio
Novelty: 0.02023782
p_int: 0.999984752
p_ni: 0.000015248
Data Source: BioPlex
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999981625
p_ni: 0.000018375
Data Source: BioPlex
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.999925426
p_ni: 0.000074574
Data Source: BioPlex
CLK2
Tchem
Family: Kinase
Novelty: 0.13068449
p_int: 0.999811657
p_ni: 0.000188343
Score: 0.439
Data Source: BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.999662255
p_ni: 0.000337744
Data Source: BioPlex
ZFC3H1
Tbio
Novelty: 0.17313739
p_int: 0.999603243
p_ni: 0.000392604
p_wrong: 0.000004154
Data Source: BioPlex
ZNF597
Tbio
Family: TF
Novelty: 0.04420398
p_int: 0.999472162
p_ni: 0.000527726
p_wrong: 1.13e-7
Score: 0.226
Data Source: BioPlex,STRINGDB
KLHL40
Tbio
Novelty: 0.0432945
p_int: 0.999345522
p_ni: 0.000654432
p_wrong: 4.6e-8
Data Source: BioPlex
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.998918159
p_ni: 0.000982927
p_wrong: 0.000098914
Data Source: BioPlex
Publication Statistics
PubMed Score  4.02

PubMed score by year
PubTator Score  2.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer