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Tbio
ATP6V1C2
V-type proton ATPase subunit C 2

Protein Summary
Description
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272238
  • ENSP00000272238
  • ENSG00000143882
  • ENST00000381661
  • ENSP00000371077

Symbol
  • VMA5
  • ATP6C2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
interacting protein
0.85
disease perturbation
0.68
histone modification site profile
0.67
PubMedID
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.5   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.5   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (92)
1 – 10 of 92
ATP6V1E2
Tbio
Family: Enzyme
Novelty: 0.10447007
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP6V1G2
Tbio
Family: Enzyme
Novelty: 0.10663259
p_int: 0.999999902
p_ni: 9.6e-8
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
ATP6V1E1
Tbio
Family: Enzyme
Novelty: 0.04832113
p_int: 0.999998952
p_ni: 0.000001048
Score: 0.998
Data Source: BioPlex,STRINGDB
ATP6V1C1
Tbio
Family: Enzyme
Novelty: 0.03660846
p_int: 0.999994923
p_ni: 0.000005077
Score: 0.911
Data Source: BioPlex,STRINGDB
ATP6V1F
Tbio
Family: Enzyme
Novelty: 0.07109314
p_int: 0.999980476
p_ni: 0.000019524
Score: 0.998
Data Source: BioPlex,STRINGDB
ATP6V1B2
Tchem
Family: Enzyme
Novelty: 0.01767911
p_int: 0.999972141
p_ni: 0.000027859
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
p_int: 0.999956165
p_ni: 0.000043835
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP6V1A
Tbio
Family: Enzyme
Novelty: 0.00921474
p_int: 0.999725722
p_ni: 0.000274278
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
p_int: 0.999626012
p_ni: 0.000373908
p_wrong: 8.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
DMXL1
Tdark
Novelty: 0.0234264
p_int: 0.999415074
p_ni: 0.000584872
p_wrong: 5.4e-8
Score: 0.832
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.50

PubMed score by year
PubTator Score  5.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer