Protein Summary
May be involved in neuronal migration. This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
- ENST00000367295
- ENSP00000356264
- ENSG00000134369
- ENST00000367296
- ENSP00000356265
- KIAA1151
- KIAA1213
- POMFIL3
- STEERIN1
- POMFIL3
- UNC53H1
- STEERIN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
drug perturbation | 0.96 | ||
virus perturbation | 0.88 | ||
PubMedID | 0.87 | ||
small molecule perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.45 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 66 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.45 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 66 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0