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Tdark
WFDC11
Protein WFDC11

Protein Summary
Description
This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324384
  • ENSP00000318753
  • ENSG00000180083
  • ENST00000356562
  • ENSP00000348968
  • ENST00000618797
  • ENSP00000479579

Symbol
  • WAP11
  • WAP11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.41
chemical
0.41
tissue
0.37
phenotype
0.36
tissue sample
0.31


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
2
2
46.8
mathematical ability
1
1
1
28.1
depressive symptom measurement
1
1
0
1.2
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
46.8
mathematical ability
1
28.1
depressive symptom measurement
0
1.2
26.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WAP four-disulfide core domain 11
VGNC:10141
741345
Mouse
MGI:3651686
629761
Rat
RGD:1596469
685227
Dog
WAP four-disulfide core domain 11 [Source:HGNC Symbol;Acc:HGNC:20478]
Cow
WAP four-disulfide core domain 11
VGNC:36932
767987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WAP four-disulfide core domain 11
Mouse
Rat
Dog
WAP four-disulfide core domain 11 [Source:HGNC Symbol;Acc:HGNC:20478]
Cow
WAP four-disulfide core domain 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NEX6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (6)
1 – 6 of 6
WFDC8
Tdark
Novelty:  0.3858941
Score:  0.795
Data Source:  STRINGDB
WFDC10A
Tdark
Novelty:  0.62036702
Score:  0.741
Data Source:  STRINGDB
WFDC13
Tdark
Novelty:  0.32518794
Score:  0.703
Data Source:  STRINGDB
WFDC10B
Tdark
Novelty:  0.9331351
Score:  0.67
Data Source:  STRINGDB
WFDC1
Tbio
Novelty:  0.00933307
Score:  0.481
Data Source:  STRINGDB
WFDC2
Tbio
Novelty:  0.0136923
Score:  0.446
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.92

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer